Dammann H G, Walter T A, Müller P, Simon B
Hepatogastroenterology. 1985 Aug;32(4):191-4.
The aim of our study was to investigate both the effect of 28-day treatment with omeprazole (30 mg orally once daily) and of repeated investigations on 24 h intragastric H+ activity. In double-blind randomized order, 10 healthy subjects received omeprazole and 5 placebo. 24 h acidity was determined before, during and after, treatment on days -8, -4, -1, 14 and 28, 32, 36, 42 and 70. A 90% reduction in the 24 h acid concentration was found after 14 and 28 days of treatment. Nocturnal H+ activity was decreased by 85%. No hyperacidity was observed after withdrawal of the drug. Control levels before, (between days -8 and -1) and after, therapy (between days 36 and 70), however, showed a significant increase in 24 h intragastric H+-activity. Summarizing, omeprazole 30 mg mane inhibits gastric acidity markedly both day and night. Repeated investigations at short intervals lead to a significant increase in intragastric acid concentration.
我们研究的目的是调查奥美拉唑（每日口服一次，每次30毫克，共治疗28天）的疗效以及重复检测对24小时胃内H⁺活性的影响。10名健康受试者按双盲随机顺序服用奥美拉唑，5名服用安慰剂。在治疗前、治疗期间和治疗后的第-8、-4、-1、14和28天，以及第32、36、42和70天测定24小时胃酸度。治疗14天和28天后，24小时胃酸浓度降低了90%。夜间H⁺活性降低了85%。停药后未观察到胃酸过多。然而，治疗前（第-8天至-1天之间）和治疗后（第36天至70天之间）的对照水平显示，24小时胃内H⁺活性显著增加。总之，每日一次30毫克的奥美拉唑显著抑制昼夜胃酸分泌。短时间间隔的重复检测导致胃内酸浓度显著增加。
