Villalba Marta, Sabates Victor, Orgul Sarp, Perez Victor L, Swaminathan Swarup S, Sabater Alfonso L
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL, 33136, USA.
Department of Ophthalmology, Duke Eye Center, Duke University School of Medicine, Durham, NC, USA.
Ophthalmol Ther. 2024 Sep;13(9):2393-2404. doi: 10.1007/s40123-024-00998-9. Epub 2024 Jul 19.
This study aimed to analyze corneal sensitivity with a new noncontact and handheld esthesiometer (Brill Engines, Spain) in patients with dry eye disease (DED) and patients on hypotensive drops, and to compare it with healthy subjects.
A total of 31 patients (57 eyes) with DED, 23 patients (46 eyes) with glaucoma, and 21 healthy patients (33 eyes) were recruited. In all patients, corneal sensitivity was measured. Subsequently, a keratography test (Keratograph 5M, Oculus) was carried out to measure tear meniscus height (TMH), non-invasive breakup time (NIBUT), bulbar redness (Jenvis scale), and corneal staining (CS, Oxford scale). Both corneal sensitivity and ocular surface parameters were compared between DED, glaucoma, and healthy subjects. Linear mixed models were constructed to utilize data from both eyes of patients. An alpha level of 0.05 was considered statistically significant.
The mean age was 56.1 ± 16.1 years in the DED group, 69.5 ± 11.7 years in the glaucoma group, and 37.190 ± 11.677 years in the control group. After adjustment for age and sex, corneal sensitivity was significantly reduced in DED and glaucoma vs control group (P = 0.02 and P = 0.009, respectively). NIBUT was lower in DED and glaucoma groups (P < 0.001 and P = 0.001, respectively). Redness and CS values were higher in the DED group (P = 0.04 and P = 0.001, respectively). TMH was lower in the glaucoma group (P = 0.03).
Corneal sensitivity measured with a novel noncontact esthesiometer was reduced in DED and glaucoma groups compared to controls. In clinical practice, this esthesiometer could be an easy-to-use device to screen for patients with subclinical neurotrophic keratopathy.
本研究旨在使用一种新型非接触式手持角膜知觉计（西班牙布里尔引擎公司）分析干眼症（DED）患者和使用降压眼药水患者的角膜敏感性，并与健康受试者进行比较。
共招募了31例DED患者（57只眼）、23例青光眼患者（46只眼）和21例健康患者（33只眼）。对所有患者测量角膜敏感性。随后，进行角膜地形图检查（Oculus公司的Keratograph 5M）以测量泪河高度（TMH）、非侵入性泪膜破裂时间（NIBUT）、球结膜充血（詹维斯量表）和角膜染色（CS，牛津量表）。比较DED组、青光眼组和健康受试者的角膜敏感性和眼表参数。构建线性混合模型以利用患者双眼的数据。α水平设定为0.05，差异具有统计学意义。
DED组的平均年龄为56.1±16.1岁，青光眼组为69.5±11.7岁，对照组为37.190±11.677岁。在对年龄和性别进行调整后，DED组和青光眼组的角膜敏感性与对照组相比显著降低（分别为P = 0.02和P = 0.009）。DED组和青光眼组的NIBUT较低（分别为P < 0.001和P = 0.001）。DED组的充血和CS值较高（分别为P = 0.04和P = 0.001）。青光眼组的TMH较低（P = 0.03）。
与对照组相比，DED组和青光眼组使用新型非接触式角膜知觉计测量的角膜敏感性降低。在临床实践中，这种角膜知觉计可能是一种易于使用的设备，用于筛查亚临床神经营养性角膜病变患者。
