Department of Psychology, Northeastern University, Boston, MA, USA.
Laboratory of Cognitive and Clinical Neurophysiology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City, Mexico.
J Parkinsons Dis. 2024;14(5):999-1013. doi: 10.3233/JPD-230458.
Research indicates that people with Parkinson's disease (PwPs) may experience challenges in both peripheral and central auditory processing, although findings are inconsistent across studies. Due to the diversity of auditory measures used, there is a need for standardized, replicable hearing assessments to clarify which aspects of audition are impacted in PWPs and whether they are linked to motor and non-motor symptoms.
To characterize auditory processes and their possible alteration in PwPs. To address this, we collected a comprehensive set of standardized measures of audition using PART, a digital testing platform designed to facilitate replication. Additionally, we examined the relationship between auditory, cognitive, and clinical variables in PwPs.
We included 44 PwPs and 54 age and education matched healthy controls. Assessments included detection of diotic and dichotic frequency modulation, temporal gaps, spectro-temporal broad-band modulation, and speech-on-speech masking.
We found no statistically significant differences in auditory processing measures between PwPs and the comparison group (ps > 0.07). In PwPs, an auditory processing composite score showed significant medium size correlations with cognitive measures (0.39 < r<0.41, ps < 0.02) and clinical variables of motor symptom severity, quality of life, depression, and caretaker burden (0.33 < r<0.52, ps < 0.03).
While larger datasets are needed to clarify whether PwPs experience more auditory difficulties than healthy controls, our results underscore the importance of considering auditory processing on the symptomatic spectrum of Parkinson's disease using standardized replicable methodologies.
研究表明，帕金森病（PD）患者可能在周围和中枢听觉处理方面都存在困难，尽管不同研究的结果不一致。由于使用的听觉测量方法多样，因此需要标准化、可复制的听力评估，以明确哪些方面的听觉受到影响，以及它们是否与运动和非运动症状有关。
描述帕金森病患者的听觉过程及其可能的变化。为此，我们使用 PART 收集了一套全面的听觉标准化测量，PART 是一个数字测试平台，旨在促进复制。此外，我们还研究了帕金森病患者的听觉、认知和临床变量之间的关系。
我们纳入了 44 名帕金森病患者和 54 名年龄和教育程度相匹配的健康对照者。评估包括检测双音调及双声道频率调制、时间间隙、频谱-时间宽带调制和语音对语音掩蔽。
我们未发现帕金森病患者与对照组之间的听觉处理测量存在统计学显著差异（p＞0.07）。在帕金森病患者中，听觉处理综合评分与认知测量（0.39＜r＜0.41，p＜0.02）和运动症状严重程度、生活质量、抑郁和照顾者负担等临床变量（0.33＜r＜0.52，p＜0.03）具有显著的中等大小相关性。
虽然需要更大的数据集来阐明帕金森病患者是否比健康对照者有更多的听觉困难，但我们的结果强调了使用标准化、可复制的方法，在帕金森病的症状谱上考虑听觉处理的重要性。
