Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, CO, USA.
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA.
J Parkinsons Dis. 2024;14(6):1095-1103. doi: 10.3233/JPD-240228.
Pre-formed fibrils (PFFs) made from recombinant α-synuclein are broadly used throughout the field in cellular and animal models of Parkinson's disease. However, their ability to successfully recapitulate disease biology is a controversial topic. In this article, two researchers debate this issue with Amanda Woerman taking the view that PFFs are a model of synucleinopathy but not Parkinson's disease, while Kelvin Luk defends their use as an important tool in the field.
由重组α-突触核蛋白制成的预形成纤维（PFFs）在帕金森病的细胞和动物模型领域被广泛应用。然而，它们成功再现疾病生物学的能力是一个有争议的话题。在这篇文章中，两位研究人员就此问题展开了辩论，Amanda Woerman 认为 PFFs 是一种突触核蛋白病模型，但不是帕金森病模型，而 Kelvin Luk 则为其作为该领域的重要工具进行了辩护。
