Digestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, Colorado, USA.
Gastrointestinal Eosinophilic Diseases Program, Children's Hospital Colorado, Section of Allergy and Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA.
J Pediatr Gastroenterol Nutr. 2024 Sep;79(3):631-635. doi: 10.1002/jpn3.12323. Epub 2024 Jul 20.
The 1-h esophageal string test (EST) is a minimally invasive test that can be used to monitor eosinophilic esophagitis (EoE) disease activity and guide treatment without endoscopy. We aimed to describe the real-world utilization and impact of EST on the care of children with EoE over the first year this was used at our center. Between 12/1/2022 and 11/30/2023, 39 ESTs were successful in 45 attempts (87% completion rate) in 31 patients. Five patients underwent multiple ESTs. Adverse events during the EST included vomiting. Reasons for failure to complete the EST (13%, n = 6) were patients could not swallow the capsule (n = 5) and vomiting (n = 1). EST was used to assess EoE without the need for endoscopy in 95% (n = 37) of cases. Treatment approach varied based on whether the EST indicated active (38.5%) or inactive (61.5%) EoE. The EST is a well-tolerated minimally invasive disease monitoring tool for patients with EoE.
1 小时食管串珠试验（EST）是一种微创检测方法，可用于监测嗜酸性食管炎（EoE）的疾病活动情况，并在无需内镜检查的情况下指导治疗。我们旨在描述 EST 在我们中心使用的第一年中，其在监测儿童 EoE 疾病活动方面的实际应用和影响。在 2022 年 12 月 1 日至 2023 年 11 月 30 日期间，31 名患者中有 39 次 EST 尝试（完成率为 87%）取得了成功。有 5 名患者进行了多次 EST。EST 过程中出现的不良事件包括呕吐。EST 检测未能完成的原因包括 5 名患者无法吞咽胶囊（n = 5）和呕吐（n = 1）。EST 在 95%（n = 37）的情况下被用于评估无需内镜检查的 EoE。根据 EST 是否提示 EoE 处于活动期（38.5%）或非活动期（61.5%），治疗方法也有所不同。EST 是一种耐受性良好的微创疾病监测工具，适用于 EoE 患者。
