Department of Biotechnology, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India.
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, India.
Biochim Biophys Acta Rev Cancer. 2024 Sep;1879(5):189158. doi: 10.1016/j.bbcan.2024.189158. Epub 2024 Jul 18.
Tumor microenvironment is formed by various cellular and non-cellular components which interact with one another and form a complex network of interactions. Some of these cellular components also attain a secretory phenotype and release growth factors, cytokines, chemokines etc. in the surroundings which are capable of inducing even greater number of signalling networks. All these interactions play a decisive role in determining the course of tumorigenesis. The treatment strategies against cancer also exert their impact on the local microenvironment. Such interactions and anticancer therapies have been found to induce more deleterious outcomes like immunosuppression and chemoresistance in the process of tumor progression. Hence, understanding the tumor microenvironment is crucial for dealing with cancer and chemoresistance. This review is an attempt to develop some understanding about the tumor microenvironment and different factors which modulate it, thereby contributing to tumorigenesis. Along with summarising the major components of tumor microenvironment and various interactions taking place between them, it also throws some light on how the existing and potential therapies exert their impact on these dynamics.
肿瘤微环境由各种细胞和非细胞成分组成，它们相互作用并形成一个复杂的相互作用网络。其中一些细胞成分也获得了分泌表型，并在周围环境中释放生长因子、细胞因子、趋化因子等，这些因子能够诱导更多的信号网络。所有这些相互作用在决定肿瘤发生过程中起着决定性的作用。抗癌治疗策略也会对局部微环境产生影响。在肿瘤进展过程中，这些相互作用和抗癌治疗被发现会诱导免疫抑制和化疗耐药等更具危害性的后果。因此，了解肿瘤微环境对于应对癌症和化疗耐药性至关重要。这篇综述试图对肿瘤微环境以及调节它的不同因素有一些了解，从而促进肿瘤发生。本文总结了肿瘤微环境的主要成分以及它们之间发生的各种相互作用，还探讨了现有的和潜在的治疗方法如何对这些动态产生影响。
