Endo L, Corman L C, Panush R S
Med Clin North Am. 1985 Jul;69(4):623-36. doi: 10.1016/s0025-7125(16)31011-2.
There are now many assays for the quantification of circulating immune complexes, each with distinct specificity and sensitivity. In a wide variety of rheumatic, infectious, neoplastic, and metabolic conditions, levels of circulating immune complexes may be elevated. In select situations, determination of circulating immune complex levels may help clinicians in the management of their patients. In lupus erythematosus, circulating immune complex levels, in conjunction with other immune parameters, may provide more insight into the disease course and activity than assessment of end organ parameters alone. In the differential diagnosis of infective endocarditis, serial levels of circulating immune complexes may provide evidence of effectiveness or failure of treatment. There is evidence that assays for circulating immune complexes may be of potential benefit in the management of Lyme disease and acute myelogenous leukemia.
目前有许多用于定量循环免疫复合物的检测方法，每种方法都有独特的特异性和灵敏度。在多种风湿性、感染性、肿瘤性和代谢性疾病中，循环免疫复合物水平可能会升高。在某些情况下，测定循环免疫复合物水平可能有助于临床医生管理患者。在红斑狼疮中，与其他免疫参数一起，循环免疫复合物水平可能比仅评估终末器官参数更能深入了解疾病进程和活动情况。在感染性心内膜炎的鉴别诊断中，循环免疫复合物的系列水平可能提供治疗有效性或失败的证据。有证据表明，循环免疫复合物检测在莱姆病和急性髓细胞白血病的管理中可能具有潜在益处。
