Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518109, China; Precision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519000, China.
Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babil 51001, Hilla, Iraq.
Cytokine. 2024 Oct;182:156699. doi: 10.1016/j.cyto.2024.156699. Epub 2024 Jul 20.
Psoriasis, a prevalent inflammatory skin condition impacting millions globally, continues to pose treatment challenges, despite the availability of multiple therapies. This underscores the demand for innovative treatments. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their capacity to modulate the immune system and facilitate tissue healing. Recent research indicates that MSCs don't just work through direct cell-to-cell interactions but also release extracellular vesicles (EVs), containing various bioactive substances like proteins, lipids, and nucleic acids. This article explores our current knowledge of psoriasis's origins and the potential utilization of MSCs and their EVs, particularly exosomes, in managing the condition. Additionally, we delve into how MSCs and EVs function in therapy, including their roles in regulating immune responses and promoting tissue repair. Lastly, we discuss the obstacles and opportunities associated with translating MSC-based treatments for psoriasis into clinical practice.
银屑病，一种常见的炎症性皮肤疾病，影响着全球数百万人，尽管有多种治疗方法，但仍存在治疗挑战。这突显了对创新治疗方法的需求。间充质干细胞 (MSCs) 由于能够调节免疫系统和促进组织愈合，已成为一种有前途的治疗选择。最近的研究表明，MSCs 不仅通过直接的细胞间相互作用发挥作用，还释放含有各种生物活性物质（如蛋白质、脂质和核酸）的细胞外囊泡 (EVs)。本文探讨了我们对银屑病起源的现有认识，以及 MSCs 及其 EVs（特别是外泌体）在管理该疾病方面的潜在应用。此外，我们还深入探讨了 MSCs 和 EVs 在治疗中的作用，包括它们在调节免疫反应和促进组织修复方面的作用。最后，我们讨论了将基于 MSC 的银屑病治疗方法转化为临床实践所面临的障碍和机遇。
