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全基因组选择揭示了与湖羊多乳头相关的候选基因。

Genome-wide selection reveals candidate genes associated with multiple teats in Hu sheep.

机构信息

College of Animal Science and Technology, Tarim University, Xinjiang, China.

出版信息

Anim Biotechnol. 2024 Nov;35(1):2380766. doi: 10.1080/10495398.2024.2380766. Epub 2024 Jul 21.

Abstract

Increasing the number of teats in sheep helps to improve the survival rate of sheep lambs after birth. In order to analyze the candidate genes related to the formation of multiple teats in Hu sheep, the present study was conducted to investigate the genetic pattern of multiple teats in Hu sheep. In this study, based on genome-wide data from 157 Hu sheep, Fst, xp-EHH, Pi and iHS signaling were performed, and the top 5% signal regions of each analyzed result were annotated based on the Oar_v4.0 for sheep. The results show that a total of 142 SNP loci were selected. We found that and genes were closely associated with polypodium formation in Hu sheep, in addition, among the candidate genes related to polypodium we found genes such as and related to milk traits. The present study screened out candidate genes for the formation of multiple teats at the genomic level in Hu sheep.

摘要

增加羊的乳头数量有助于提高绵羊羔羊出生后的存活率。为了分析与湖羊多乳头形成相关的候选基因,本研究旨在探讨湖羊多乳头的遗传模式。在这项研究中,基于 157 只湖羊的全基因组数据,进行了 Fst、xp-EHH、Pi 和 iHS 信号分析,并根据绵羊的 Oar_v4.0 对每个分析结果的前 5%信号区域进行了注释。结果表明,共选择了 142 个 SNP 位点。我们发现 和 基因与湖羊多乳头形成密切相关,此外,在与多乳头形成相关的候选基因中,我们发现了与奶性状相关的基因,如 和 。本研究在基因组水平上筛选出了湖羊多乳头形成的候选基因。

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