Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China.
Genes (Basel). 2024 Apr 26;15(5):551. doi: 10.3390/genes15050551.
A genomic study was conducted to uncover the selection signatures in sheep that show extremely significant differences in growth traits under the same breed, age in months, nutrition level, and management practices. Hu sheep from Gansu Province and Gangba sheep from the Tibet Autonomous Region in China were selected. We collected whole-genome data from 40 sheep individuals (24 Hu sheep and 16 Gangba sheep), through whole-genome sequencing. Selection signals were analyzed using parameters such as F, π , and Tajima's D. We have identified several candidate genes that have undergone strong selection, particularly those associated with growth traits. Specifically, five growth-related genes were identified in both the Hu sheep group (, , , , ) and the Gangba sheep group (, , , , ). Additionally, in a genomic region strongly selected in both the Hu and Gangba sheep groups (Chr 22: 51,425,001-51,500,000), the growth-associated gene was identified, further highlighting the genetic factors influencing growth characteristics in these breeds. This study analyzes the genetic basis for significant differences in sheep phenotypes, identifies candidate genes related to sheep growth traits, lays the foundation for molecular genetic breeding in sheep, and accelerates the genetic improvement in livestock.
进行了一项基因组研究，以揭示在中国甘肃地区的湖羊和西藏自治区的岗巴羊这两个品种中，在相同的品种、月龄、营养水平和管理实践下，生长性状存在显著差异的选择特征。我们从 40 只羊个体（24 只湖羊和 16 只岗巴羊）中收集了全基因组数据，通过全基因组测序。使用 F、π 和 Tajima 的 D 等参数分析了选择信号。我们已经确定了几个经历了强烈选择的候选基因，特别是与生长性状相关的基因。具体来说，在湖羊组（、、、、）和岗巴羊组（、、、、）中都鉴定到了五个与生长相关的基因。此外，在湖羊和岗巴羊两个群体中都强烈选择的一个基因组区域（Chr 22：51,425,001-51,500,000）中，鉴定到了与生长相关的基因，这进一步强调了影响这些品种生长特征的遗传因素。本研究分析了绵羊表型差异的遗传基础，鉴定了与绵羊生长性状相关的候选基因，为绵羊的分子遗传育种奠定了基础，并加速了家畜的遗传改良。
