Harbin T J
Neurobehav Toxicol Teratol. 1985 Jul-Aug;7(4):339-44.
There is an urgent need for efficient, non-invasive measures of neurotoxic insult in humans. The late positive component (LPC) of the event-related cortical potential may be such a measure. The latency and amplitude of the LPC have been related to both memory and response speed, two aspects of behavior which are indicators of neurological status. The LPC has been found to be altered in cases of known neurophysiological insult, including Alzheimer's disease, cerebrovascular disease, Parkinson's disease, surgical and traumatic damage, hyperkinesis, chronic alcoholism, mental retardation, and in schizophrenia. Further development of the LPC as a possible indicator of both the cognitive impairment due to neurotoxic substances as well as the site of neurological damage is warranted.
迫切需要针对人类神经毒性损伤的高效、非侵入性检测方法。事件相关皮层电位的晚期正成分（LPC）可能就是这样一种检测方法。LPC的潜伏期和波幅与记忆和反应速度都有关，而这两个行为方面都是神经状态的指标。已发现，在已知的神经生理损伤病例中，包括阿尔茨海默病、脑血管疾病、帕金森病、手术和外伤损害、运动亢进、慢性酒精中毒、智力迟钝以及精神分裂症，LPC都会发生改变。有必要进一步开发LPC，使其成为神经毒性物质所致认知障碍以及神经损伤部位的一种可能指标。
