• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

组蛋白乳酸化相关基因与癌症相关成纤维细胞的分子模式和功能相关，在透明细胞肾细胞癌中具有重要的临床意义。

Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma.

作者信息

Kong Weiyu, He Jiaxin, Zhou Qinyao, Zhou Xin, Wei Xiyi, Yang Yonglin, Mei Yiwen, Wang Shuai, Zhang Xi, Yao Bing, Yue Yulin, Xu Jiali, Jiang Minjun, Xu Chen

机构信息

Department of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, 215000, China.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

出版信息

Heliyon. 2024 Jun 24;10(13):e33554. doi: 10.1016/j.heliyon.2024.e33554. eCollection 2024 Jul 15.

DOI:10.1016/j.heliyon.2024.e33554
PMID:39035489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11259888/
Abstract

Recent research emphasised the indispensable role of histone lactylation in the activation of hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell carcinoma, which normally causes a metabolic shift in cancer cells and increases lactate production, eventually creating a lactate-enriched tumour microenvironment. Cancer-associated fibroblasts (CAFs) promote tumour progression, which is also vital in clear cell renal cell carcinoma. Therefore, this study investigated histone lactylation in CAFs and its impact on patient survival. Multiomics technology was employed to determine the role of histone lactylation-related genes in the evolution of CAFs which correlated with the function and molecular signatures of CAFs. The results suggested that TIMP1 was the hub gene of histone lactylation-related genes in clear cell renal cell carcinoma.

摘要

近期研究强调了组蛋白乳酸化在肝星状细胞激活中的不可或缺作用。VHL突变在透明细胞肾细胞癌中极为常见，这通常会导致癌细胞发生代谢转变并增加乳酸生成，最终形成富含乳酸的肿瘤微环境。癌症相关成纤维细胞（CAFs）促进肿瘤进展，这在透明细胞肾细胞癌中也至关重要。因此，本研究调查了CAFs中的组蛋白乳酸化及其对患者生存的影响。采用多组学技术来确定组蛋白乳酸化相关基因在CAFs演变中的作用，这些基因与CAFs的功能和分子特征相关。结果表明，TIMP1是透明细胞肾细胞癌中组蛋白乳酸化相关基因的枢纽基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/dfaa1a27a93e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/86a5c2be83b5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/035ae3e2772a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/03ff893029da/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/d716dc019ff1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/7de4ac316fbf/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/6aca04008b95/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/dd91186e90fd/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/60541eebe096/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/dfaa1a27a93e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/86a5c2be83b5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/035ae3e2772a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/03ff893029da/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/d716dc019ff1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/7de4ac316fbf/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/6aca04008b95/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/dd91186e90fd/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/60541eebe096/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f6/11259888/dfaa1a27a93e/gr9.jpg

相似文献

1
Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma.组蛋白乳酸化相关基因与癌症相关成纤维细胞的分子模式和功能相关，在透明细胞肾细胞癌中具有重要的临床意义。
Heliyon. 2024 Jun 24;10(13):e33554. doi: 10.1016/j.heliyon.2024.e33554. eCollection 2024 Jul 15.
2
A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression.非活性 VHL 触发的组蛋白乳酰化与 PDGFRβ 信号之间的正反馈环驱动肾透明细胞癌的进展。
Int J Biol Sci. 2022 May 13;18(8):3470-3483. doi: 10.7150/ijbs.73398. eCollection 2022.
3
Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma.新型乳糖化相关特征可预测胰腺腺癌的预后。
World J Gastroenterol. 2024 May 21;30(19):2575-2602. doi: 10.3748/wjg.v30.i19.2575.
4
Identification of lactylation gene CALML5 and its correlated lncRNAs in cutaneous melanoma by machine learning.机器学习鉴定皮肤黑色素瘤中的乳酰化基因 CALML5 及其相关 lncRNAs。
Medicine (Baltimore). 2023 Nov 24;102(47):e35999. doi: 10.1097/MD.0000000000035999.
5
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis.己糖激酶 2 通过组蛋白乳酰化介导的基因表达是肝星状细胞激活和肝纤维化所必需的。
Cell Metab. 2023 Aug 8;35(8):1406-1423.e8. doi: 10.1016/j.cmet.2023.06.013. Epub 2023 Jul 17.
6
Metabolic regulation of gene expression by histone lactylation.组蛋白乳酰化对基因表达的代谢调控。
Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. Epub 2019 Oct 23.
7
Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma.糖酵解与组蛋白乳酰化之间的正反馈调节促进胰腺导管腺癌的发生。
Mol Cancer. 2024 May 6;23(1):90. doi: 10.1186/s12943-024-02008-9.
8
Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription.组蛋白乳酰化在代谢重编程和表观遗传重排中架起桥梁，推动致癌作用发生：代谢物为致癌转录提供燃料。
Clin Transl Med. 2024 Mar;14(3):e1614. doi: 10.1002/ctm2.1614.
9
Prognostic impact of lactylation-associated gene modifications in clear cell renal cell carcinoma: Insights into molecular landscape and therapeutic opportunities.透明细胞肾细胞癌中与乳糖化相关的基因修饰的预后影响：对分子景观和治疗机会的深入了解。
Environ Toxicol. 2024 Mar;39(3):1360-1373. doi: 10.1002/tox.24040. Epub 2023 Nov 16.
10
Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia.缺氧通过组蛋白乳糖化调节子痫前期患者胎盘纤维化相关基因。
J Hypertens. 2022 Jun 1;40(6):1189-1198. doi: 10.1097/HJH.0000000000003129.

引用本文的文献

1
Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications.疾病中的组蛋白乳酰化：中医药的调控作用及治疗意义
Drug Des Devel Ther. 2025 Jul 29;19:6435-6459. doi: 10.2147/DDDT.S524008. eCollection 2025.
2
Lactate-Mediated Crosstalk Between Tumor Cells and Cancer-Associated Fibroblasts: Mechanisms and Therapeutic Opportunities.肿瘤细胞与癌症相关成纤维细胞之间的乳酸介导的串扰：机制与治疗机会
Int J Mol Sci. 2025 Jun 11;26(12):5583. doi: 10.3390/ijms26125583.
3
Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer.

本文引用的文献

1
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis.己糖激酶 2 通过组蛋白乳酰化介导的基因表达是肝星状细胞激活和肝纤维化所必需的。
Cell Metab. 2023 Aug 8;35(8):1406-1423.e8. doi: 10.1016/j.cmet.2023.06.013. Epub 2023 Jul 17.
2
Mesenchymal-like Tumor Cells and Myofibroblastic Cancer-Associated Fibroblasts Are Associated with Progression and Immunotherapy Response of Clear Cell Renal Cell Carcinoma.间充质样肿瘤细胞和肌纤维母细胞性癌症相关成纤维细胞与肾透明细胞癌的进展和免疫治疗反应相关。
Cancer Res. 2023 Sep 1;83(17):2952-2969. doi: 10.1158/0008-5472.CAN-22-3034.
3
癌症相关成纤维细胞营造高乳酸微环境以驱动胰腺癌的神经周围浸润。
Cancer Res. 2025 Jun 16;85(12):2199-2217. doi: 10.1158/0008-5472.CAN-24-3173.
4
Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies.癌症中的乳酸化修饰：机制、功能及治疗策略。
Exp Hematol Oncol. 2025 Mar 8;14(1):32. doi: 10.1186/s40164-025-00622-x.
5
Lactylation in health and disease: physiological or pathological?健康与疾病中的乳酸化：生理还是病理？
Theranostics. 2025 Jan 2;15(5):1787-1821. doi: 10.7150/thno.105353. eCollection 2025.
Elastic Net Regularization Paths for All Generalized Linear Models.
所有广义线性模型的弹性网络正则化路径
J Stat Softw. 2023;106. doi: 10.18637/jss.v106.i01. Epub 2023 Mar 23.
4
Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.Parkin 定向的线粒体健康状况通过组蛋白乳酰化的代谢调节控制癌细胞命运。
Cell Rep. 2023 Feb 28;42(2):112033. doi: 10.1016/j.celrep.2023.112033. Epub 2023 Jan 31.
5
Integrative Single-Cell Analysis Reveals Transcriptional and Epigenetic Regulatory Features of Clear Cell Renal Cell Carcinoma.整合单细胞分析揭示透明细胞肾细胞癌的转录和表观遗传调控特征。
Cancer Res. 2023 Mar 2;83(5):700-719. doi: 10.1158/0008-5472.CAN-22-2224.
6
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.乳酰化组分析提示肝细胞癌中存在依赖乳酰化的代谢适应机制。
Nat Metab. 2023 Jan;5(1):61-79. doi: 10.1038/s42255-022-00710-w. Epub 2023 Jan 2.
7
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression.乳酸化-乳酸化手之间的代谢重编程和免疫抑制。
Int J Mol Sci. 2022 Oct 8;23(19):11943. doi: 10.3390/ijms231911943.
8
Scalable and model-free detection of spatial patterns and colocalization.可扩展且无模型的空间模式和共定位检测。
Genome Res. 2022 Sep;32(9):1736-1745. doi: 10.1101/gr.276851.122. Epub 2022 Sep 9.
9
Cut loose TIMP-1: an emerging cytokine in inflammation.释放基质金属蛋白酶组织抑制因子-1：一种在炎症中崭露头角的细胞因子。
Trends Cell Biol. 2023 May;33(5):413-426. doi: 10.1016/j.tcb.2022.08.005. Epub 2022 Sep 23.
10
Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer.空间转录组图谱揭示结直肠癌中肿瘤相关成纤维细胞与肿瘤微环境成分的相互作用。
J Transl Med. 2022 Jul 6;20(1):302. doi: 10.1186/s12967-022-03510-8.