Hooshiar Mohammad Hosseini, Sholeh Mohammad, Beig Masoumeh, Azizian Khalil, Kouhsari Ebrahim
Department of Periodontology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Front Pharmacol. 2024 Jul 3;15:1284665. doi: 10.3389/fphar.2024.1284665. eCollection 2024.
Antimicrobial resistance (AMR) of (NG) is a significant public health concern.
The objective of our study was to assess global AMR rates and test them both temporally and geographically.
We conducted a systematic search of relevant reports from international databases up to 2021. The R statistical package was used for all statistical analyses.
A total of 225 articles were analyzed, and 432,880 NG isolates were examined. The weighted pooled resistance (WPR) rate of different antibiotics was as follows: ciprofloxacin, 51.6%; tetracycline, 45.4%; trimethoprim/sulfamethoxazole, 42.4%; chloramphenicol, 4.1%; kanamycin, 2.1%; gentamicin, 0.6%; and spectinomycin, 0.3%. The resistance to spectinomycin, gentamicin, and kanamycin decreased over time. Significant differences in antibiotic resistance rates were found between the countries.
Our findings reveal a continuous increase in resistance to some antibiotics (tetracycline and ciprofloxacin) historically used for gonorrhea, even after discontinuation. However, encouraging trends of decreasing resistance to spectinomycin, gentamicin, and kanamycin were observed. Continued global monitoring of AMR profiles in NG isolates is essential for informing appropriate treatment strategies and mitigating the threat of untreatable gonorrhea.
淋球菌（NG）的抗菌药物耐药性（AMR）是一个重大的公共卫生问题。
我们研究的目的是评估全球AMR率，并在时间和地理上对其进行检测。
我们对截至2021年的国际数据库中的相关报告进行了系统检索。所有统计分析均使用R统计软件包。
共分析了225篇文章，检测了432,880株NG分离株。不同抗生素的加权合并耐药率（WPR）如下：环丙沙星，51.6%；四环素，45.4%；甲氧苄啶/磺胺甲恶唑，42.4%；氯霉素，4.1%；卡那霉素，2.1%；庆大霉素，0.6%；大观霉素，0.3%。对大观霉素、庆大霉素和卡那霉素的耐药性随时间下降。各国之间抗生素耐药率存在显著差异。
我们的研究结果显示，历史上用于治疗淋病的一些抗生素（四环素和环丙沙星）的耐药性持续增加，即使在停用后也是如此。然而，观察到对大观霉素、庆大霉素和卡那霉素耐药性下降的令人鼓舞的趋势。持续对NG分离株的AMR谱进行全球监测对于制定适当的治疗策略和减轻无法治疗的淋病的威胁至关重要。
