Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Front Endocrinol (Lausanne). 2024 Jul 5;15:1399859. doi: 10.3389/fendo.2024.1399859. eCollection 2024.
Metabolic syndrome(MetS) and depression are independently associated with type 2 diabetes (T2DM) risk. However, little is known about the combined effect of MetS and depression on the risk of T2DM. The present study aims to prospectively explore the impact of MetS and depression on T2DM susceptibility among the Chinese general population.
6489 general population without T2DM adults in Southwest China were recruited from 2010 to 2012. Depression and MetS were prospectively assessed using a 9-item Patient Health Questionnaire(PHQ-9) and Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition) (CDS2020) during 2016-2020, respectively. Modified Poisson regression models were conducted to estimate relative risk(RR) and 95% confidence intervals (95%CI) for independent and combined associations of MetS and depression with an incidence of T2DM.
During a median follow-up of 6.6 years, 678 cases of T2DM were documented. Individuals with MetS were 1.33 times more likely to develop T2DM than those without MetS. The corresponding RR(95%CI) for depression with no depression was 1.45(1.22-1.72). Notably, compared with no MetS or depression, the multivariate-adjusted RR for a combined effect of MetS and depression on the risk of T2DM was 2.11(1.39-3.22). Moreover, an increased risk of T2DM was more apparent in those ≥ 60 years, males, and overweight.
Individuals with multimorbidity of MetS and depression are at a higher risk of T2DM compared with those with no MetS or depression.
代谢综合征（MetS）和抑郁与 2 型糖尿病（T2DM）风险独立相关。然而，对于 MetS 和抑郁对 T2DM 风险的综合影响知之甚少。本研究旨在前瞻性探讨代谢综合征和抑郁对中国一般人群 T2DM 易感性的影响。
2010 年至 2012 年，在中国西南地区招募了 6489 名无 T2DM 的成年人。2016 年至 2020 年期间，使用 9 项患者健康问卷（PHQ-9）和《中国 2 型糖尿病防治指南（2020 年版）》（CDS2020）前瞻性评估抑郁和代谢综合征。使用校正泊松回归模型估计代谢综合征和抑郁与 T2DM 发病率独立和联合关联的相对风险（RR）和 95%置信区间（95%CI）。
在中位随访 6.6 年期间，记录了 678 例 T2DM 病例。患有代谢综合征的个体发生 T2DM 的可能性是没有代谢综合征的个体的 1.33 倍。没有抑郁的抑郁对应的 RR（95%CI）为 1.45（1.22-1.72）。值得注意的是，与没有代谢综合征或抑郁相比，代谢综合征和抑郁同时存在对 T2DM 风险的多变量校正 RR 为 2.11（1.39-3.22）。此外，≥60 岁、男性和超重的个体发生 T2DM 的风险增加更为明显。
与没有代谢综合征或抑郁的个体相比，患有代谢综合征和抑郁的多重疾病患者发生 T2DM 的风险更高。
