Intiso Domenico, Centra Antonello Marco, Gravina Michele, Copetti Massimiliano, Fontana Andrea, Bartolo Michelangelo, Filoni Serena, Di Rienzo Filomena
Unit of Neuro-rehabilitation, and Rehabilitation Medicine, IRCCS "Casa Sollievo della Sofferenza," San Giovanni Rotondo, Foggia, Italy.
Unit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza," San Giovanni Rotondo, Foggia, Italy.
Neurotrauma Rep. 2024 Jul 1;5(1):606-616. doi: 10.1089/neur.2023.0128. eCollection 2024.
Low vitamin D (VD) has been associated with poor clinical course in several neurological diseases. Supplementation has been suggested to improve outcomes. Severe acquired brain injury (sABI) subjects have low VD levels and disabling conditions requiring rehabilitation. The aim of the present study was to evaluate if VD supplementation produced a better clinical course and a better functional outcome in sABI during rehabilitation. A randomized single-blind study was performed. sABI subjects were randomized to the VD supplementation group (VDsG) (initial dose of 50.000 UI and 1.000 daily) and usual care control group (CG). Disability Rating Scale (DRS), Glasgow Outcome Scale (GOS), and Level of Cognitive Functioning (LCF) were used in assessing disability. A total of 73 subjects (42 M and 31 F; mean age 53.2 ± 15.7) were randomized: 36 (21 M and 15 F; mean age 57.52 ± 14.88) to VDsG and 37 (20 M and 17 F; mean age 48.28 ± 17.47) to CG. Both groups significantly improved after rehabilitation, and no between-group difference was observed. The mean score values for DRS, GOS, and LCF in VDsG were 18.83 ± 4.27 and 9.42 ± 5.83; 2.89 ± 0.32 and 3.78 ± 0.80; and 4.81 ± 1.70 and 7.53 ± 1.28, at admission and discharge, respectively. Likewise, mean values for DRS, GOS, and LCF in CG were 18.57 ± 4.80 and 9.84 ± 6.34; 2.84 ± 0.37 and 3.81 ± 0.94; and 4.97 ± 2.01 and 7.41 ± 1.32, respectively. VD supplementation did not improve functional outcomes in sABI during rehabilitation treatment.
低维生素D（VD）与多种神经系统疾病的不良临床病程相关。有人建议补充维生素D以改善预后。严重获得性脑损伤（sABI）患者维生素D水平较低，且存在需要康复治疗的致残状况。本研究的目的是评估补充维生素D是否能使sABI患者在康复期间获得更好的临床病程和功能预后。进行了一项随机单盲研究。将sABI患者随机分为维生素D补充组（VDsG）（初始剂量为50000国际单位，每日1000国际单位）和常规护理对照组（CG）。使用残疾评定量表（DRS）、格拉斯哥预后量表（GOS）和认知功能水平（LCF）来评估残疾情况。共有73名受试者（42名男性和31名女性；平均年龄53.2±15.7岁）被随机分组：36名（21名男性和15名女性；平均年龄57.52±14.88岁）被分入VDsG组，37名（20名男性和17名女性；平均年龄48.28±17.47岁）被分入CG组。两组在康复后均有显著改善，且未观察到组间差异。VDsG组在入院时和出院时DRS、GOS和LCF的平均得分分别为18.83±4.27和9.42±5.83；2.89±0.32和3.78±0.80；4.81±1.70和7.53±1.28。同样，CG组DRS、GOS和LCF的平均值分别为18.57±4.80和9.84±6.34；2.84±0.37和3.81±0.94；4.97±2.01和7.41±1.32。补充维生素D并不能改善sABI患者在康复治疗期间的功能预后。
