Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.
Biohazard Prevention Center, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Nutrients. 2022 Jul 4;14(13):2761. doi: 10.3390/nu14132761.
Hypovitaminosis D is a serious public health problem, representing an independent factor in mortality among the general population. Vitamin D deficiency may affect up to one billion people worldwide. Recently, the potential association between vitamin D levels and stroke has gained increasing attention. Many studies suggest that maintaining normal serum vitamin D levels is associated with improvement of the cardiovascular system and a reduction in stroke risk. As a neurosteroid, vitamin D influences brain development and function and immunomodulation and affects brain neuroplasticity. It supports many processes that maintain homeostasis in the body. As stroke is the second most common cause of death worldwide, more studies are needed to confirm the positive effects of vitamin D supplementation, its dosage at different stages of the disease, method of determination, and effect on stroke onset and recovery. Many studies on stroke survivors indicate that serum vitamin D levels only offer insignificant benefits and are not beneficial to recovery. This review article aims to highlight recent publications that have examined the potential of vitamin D supplementation to improve rehabilitation outcomes in stroke survivors. Particular attention has been paid to stroke prevention.
维生素 D 缺乏症是一个严重的公共卫生问题，是普通人群死亡率的一个独立影响因素。维生素 D 缺乏可能影响全球多达 10 亿人。最近，维生素 D 水平与中风之间的潜在关联引起了越来越多的关注。许多研究表明，维持正常的血清维生素 D 水平与改善心血管系统和降低中风风险有关。作为一种神经甾体，维生素 D 影响大脑发育和功能以及免疫调节，并影响大脑神经可塑性。它支持许多维持体内内稳态的过程。由于中风是全球第二大致死原因，因此需要更多的研究来证实维生素 D 补充的积极作用、疾病不同阶段的剂量、测定方法以及对中风发作和恢复的影响。许多关于中风幸存者的研究表明，血清维生素 D 水平仅提供微不足道的益处，对恢复没有益处。本文旨在强调最近发表的研究，这些研究探讨了维生素 D 补充对改善中风幸存者康复效果的潜力。特别关注了中风的预防。
