• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在肌肉骨骼系统中递送微型机器人。

Delivering Microrobots in the Musculoskeletal System.

作者信息

Cao Mumin, Sheng Renwang, Sun Yimin, Cao Ying, Wang Hao, Zhang Ming, Pu Yunmeng, Gao Yucheng, Zhang Yuanwei, Lu Panpan, Teng Gaojun, Wang Qianqian, Rui Yunfeng

机构信息

Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.

School of Medicine, Southeast University, Nanjing, 210009, People's Republic of China.

出版信息

Nanomicro Lett. 2024 Jul 22;16(1):251. doi: 10.1007/s40820-024-01464-8.

DOI:10.1007/s40820-024-01464-8
PMID:39037551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11263536/
Abstract

Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited efficacy. Patients often suffer chronic pain and might eventually have to undergo end-stage surgery. Therefore, future treatments should focus on early detection and intervention of regional lesions. Microrobots have been gradually used in organisms due to their advantages of intelligent, precise and minimally invasive targeted delivery. Through the combination of control and imaging systems, microrobots with good biosafety can be delivered to the desired area for treatment. In the musculoskeletal system, microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the body. Compared to traditional biomaterial and tissue engineering strategies, active motion improves the efficiency and penetration of local targeting of cells/drugs. This review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal system. We summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

摘要

肌肉骨骼系统疾病是全球疾病负担的主要成因，而目前的治疗方法疗效有限。患者常遭受慢性疼痛，最终可能不得不接受终末期手术。因此，未来的治疗应侧重于区域病变的早期检测和干预。微型机器人因其智能、精确和微创靶向递送的优势，已逐渐应用于生物体中。通过控制和成像系统的结合，可以将具有良好生物安全性的微型机器人输送到所需区域进行治疗。在肌肉骨骼系统中，微型机器人主要用于运输干细胞/药物或从体内清除有害物质。与传统生物材料和组织工程策略相比，主动运动提高了细胞/药物局部靶向的效率和穿透性。本文综述了微型机器人系统在肌肉骨骼系统不同组织中的前沿应用。我们通过评估不同微型机器人的特性，总结了阻碍临床转化的挑战和障碍，并最终指出了微型机器人在肌肉骨骼系统中的未来发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/1c3cf45c9510/40820_2024_1464_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/185d33f53d95/40820_2024_1464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/cf36adbe9841/40820_2024_1464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/7d8468981d65/40820_2024_1464_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/a85fa2eeb89f/40820_2024_1464_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/064b3e4067e3/40820_2024_1464_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/c493d274dbbc/40820_2024_1464_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/1c3cf45c9510/40820_2024_1464_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/185d33f53d95/40820_2024_1464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/cf36adbe9841/40820_2024_1464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/7d8468981d65/40820_2024_1464_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/a85fa2eeb89f/40820_2024_1464_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/064b3e4067e3/40820_2024_1464_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/c493d274dbbc/40820_2024_1464_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d08a/11263536/1c3cf45c9510/40820_2024_1464_Fig7_HTML.jpg

相似文献

1
Delivering Microrobots in the Musculoskeletal System.在肌肉骨骼系统中递送微型机器人。
Nanomicro Lett. 2024 Jul 22;16(1):251. doi: 10.1007/s40820-024-01464-8.
2
System integration of magnetic medical microrobots: from design to control.磁性医用微型机器人的系统集成：从设计到控制
Front Robot AI. 2023 Dec 19;10:1330960. doi: 10.3389/frobt.2023.1330960. eCollection 2023.
3
Development of a magnetic microrobot for carrying and delivering targeted cells.用于携带和输送靶向细胞的磁性微机器人的研制。
Sci Robot. 2018 Jun 27;3(19). doi: 10.1126/scirobotics.aat8829.
4
Self-sensing intelligent microrobots for noninvasive and wireless monitoring systems.用于无创和无线监测系统的自感应智能微型机器人。
Microsyst Nanoeng. 2023 Aug 9;9:102. doi: 10.1038/s41378-023-00574-4. eCollection 2023.
5
Fabrication of Bilayer Magnetically Actuated L-Shaped Microrobot Based on Chitosan via Photolithography.基于壳聚糖通过光刻法制备双层磁驱动L形微型机器人
Polymers (Basel). 2022 Dec 15;14(24):5509. doi: 10.3390/polym14245509.
6
Multi-level magnetic microrobot delivery strategy within a hierarchical vascularized organ-on-a-chip.多层次磁微机器人递药策略于分级血管化器官芯片内。
Lab Chip. 2024 Jan 30;24(3):446-459. doi: 10.1039/d3lc00770g.
7
Formation Techniques Used in Shape-Forming Microrobotic Systems with Multiple Microrobots: A Review.用于具有多个微型机器人的形状形成微型机器人系统的成型技术综述
Micromachines (Basel). 2022 Nov 16;13(11):1987. doi: 10.3390/mi13111987.
8
Hydrogel microrobots for biomedical applications.用于生物医学应用的水凝胶微型机器人。
Front Chem. 2024 May 22;12:1416314. doi: 10.3389/fchem.2024.1416314. eCollection 2024.
9
Microrobots for Targeted Delivery and Therapy in Digestive System.用于消化系统靶向递送与治疗的微型机器人
ACS Nano. 2023 Jan 10;17(1):27-50. doi: 10.1021/acsnano.2c04716. Epub 2022 Dec 19.
10
A Review of Single-Cell Microrobots: Classification, Driving Methods and Applications.单细胞微型机器人综述：分类、驱动方法与应用
Micromachines (Basel). 2023 Aug 31;14(9):1710. doi: 10.3390/mi14091710.

引用本文的文献

1
Free glutaraldehyde gelatin microsphere loaded mesenchymal stem cells alleviate osteoarthritis by promoting expression.负载游离戊二醛明胶微球的间充质干细胞通过促进表达来缓解骨关节炎。
Theranostics. 2025 Mar 10;15(9):4135-4146. doi: 10.7150/thno.109468. eCollection 2025.
2
Comparative efficacy of cast immobilization versus removable braces in patients with ankle fractures: a systematic review and meta-analysis.石膏固定与可拆除支具治疗踝关节骨折患者的疗效比较：一项系统评价与荟萃分析
BMC Musculoskelet Disord. 2025 Mar 11;26(1):243. doi: 10.1186/s12891-025-08451-z.
3
Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.
间充质干细胞治疗膝骨关节炎的疗效与安全性：一项随机对照试验的系统评价与Meta分析
Stem Cell Res Ther. 2025 Mar 7;16(1):122. doi: 10.1186/s13287-025-04252-2.
4
Evaluation of the comparative efficacy and safety of surgical strategies for long bone defects: a network meta-analysis.长骨缺损手术策略的比较疗效与安全性评估：一项网状Meta分析
Int J Surg. 2025 Apr 1;111(4):3030-3039. doi: 10.1097/JS9.0000000000002283.