衰老细胞分化抗原
Senescent cell differentiation antigen.
作者信息
Kay M M
出版信息
Prog Clin Biol Res. 1985;195:251-62.
PMID:3903771
Abstract
A terminal differentiation antigen, the senescent cell antigen, appears on the surface of senescent and damaged cells. Appearance of this antigen initiates immunologic binding of physiologic IgG autoantibodies and removal of the cells by macrophages. The senescent cell antigen appears to be derived from band 3, the major anion transport protein of erythrocytes. Both the senescent cell antigen and band 3 have been demonstrated in the membranes of all cells examined.
摘要
一种终末分化抗原，即衰老细胞抗原，出现在衰老和受损细胞的表面。这种抗原的出现引发生理性IgG自身抗体的免疫结合，并由巨噬细胞清除这些细胞。衰老细胞抗原似乎源自带3，即红细胞的主要阴离子转运蛋白。衰老细胞抗原和带3在所有检测细胞的膜中均已得到证实。
相似文献
1
Senescent cell differentiation antigen.衰老细胞分化抗原
Prog Clin Biol Res. 1985;195:251-62.
2
Generation of senescent cell antigen on old cells initiates IgG binding to a neoantigen.衰老细胞上衰老细胞抗原的产生引发了IgG与新抗原的结合。
Cell Mol Biol (Noisy-le-grand). 1993 Mar;39(2):131-53.
3
Poly-N-acetyllactosaminyl saccharide chains of band 3 as determinants for anti-band 3 autoantibody binding to senescent and oxidized erythrocytes.带3蛋白的多聚N-乙酰乳糖胺糖链作为抗带3自身抗体与衰老和氧化红细胞结合的决定因素。
Cell Mol Biol (Noisy-le-grand). 1996 Nov;42(7):1007-24.
4
5
Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB-MS).利用高效液相色谱法（HPLC）和快原子轰击电离质谱法（FAB-MS）对衰老细胞抗原在脑阴离子交换蛋白（AE）同工型上进行定位。
J Mol Recognit. 2004 Jan-Feb;17(1):33-40. doi: 10.1002/jmr.651.
6
Senescent cell antigen: a terminal differentiation antigen.衰老细胞抗原：一种终末分化抗原。
Surv Synth Pathol Res. 1985;4(3):227-36. doi: 10.1159/000156976.
7
8
Aging of cell membrane molecules leads to appearance of an aging antigen and removal of senescent cells.细胞膜分子老化导致衰老抗原出现以及衰老细胞的清除。
Gerontology. 1985;31(4):215-35. doi: 10.1159/000212706.
9
[Alternative complement pathway activation by anti-band 3 antibodies].[抗带3抗体激活替代补体途径]
Schweiz Med Wochenschr. 1987 Nov 14;117(46):1821-4.
10
Senescent red cell-bound IgG is attached to band 3 protein.衰老红细胞结合的免疫球蛋白G附着于带3蛋白。
Biomed Biochim Acta. 1983;42(11-12):S117-21.
Zotero 插件