Herrlen S, Kunze H
Int Pharmacopsychiatry. 1979;14(1):1-10.
A hyperactive mentally retarded patient receiving clozapin and other major tranquilizers had an unexpected seizure. The EEG revealed severe pathological patterns which disappeared after discontinuation of clozapin and could be reproduced as a function of clozapin medication. Other major tranquilizers had no particular effects. This study demonstrates how we determined whether clozapin or other major tranquilizers had seizure-promoting effects in a particular patient.
一名正在接受氯氮平及其他主要镇静剂治疗的多动型智障患者意外发生了癫痫发作。脑电图显示出严重的病理模式，在停用氯氮平后这些模式消失了，并且随着氯氮平用药情况可再次出现。其他主要镇静剂没有特别的影响。这项研究展示了我们是如何确定氯氮平或其他主要镇静剂在一名特定患者中是否具有促癫痫发作作用的。
