Department of Human Pathology and Evolutive Age "Gaetano Barresi", University of Messina, Messina, Italy.
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
Exp Dermatol. 2024 Jul;33(7):e15144. doi: 10.1111/exd.15144.
The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied in different conditions. Recent data have shown that the endocannabinoid system is responsible for maintaining the homeostasis of various skin functions such as proliferation, differentiation and release of inflammatory mediators. Because of their role in regulating these key processes, cannabinoids have been studied for the treatment of skin cancers and melanoma; their anti-tumour effects regulate skin cancer progression and are mainly related to the inhibition of tumour growth, proliferation, invasion and angiogenesis, through apoptosis and autophagy induction. This review aims at summarising the current field of research on the potential uses of cannabinoids in the melanoma field.
内源性大麻素系统由内源性脂质配体、合成和降解它们的酶以及受体组成，这些受体也可以被外源性化合物刺激，如来自大麻的化合物。大麻及其生物活性化合物，包括大麻素和非大麻素，在不同条件下已经进行了广泛研究。最近的数据表明，内源性大麻素系统负责维持各种皮肤功能的内稳态，如增殖、分化和炎症介质的释放。由于它们在调节这些关键过程中的作用，大麻素已被研究用于治疗皮肤癌和黑色素瘤；它们的抗肿瘤作用调节皮肤癌的进展，主要与通过诱导细胞凋亡和自噬来抑制肿瘤生长、增殖、侵袭和血管生成有关。本综述旨在总结大麻素在黑色素瘤领域的潜在用途的当前研究领域。
