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Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction.

作者信息

Liu Guoqing, Wang Min, Lv Xiangwen, Guan Yuting, Li Jingqi, Xie Jian

机构信息

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.

Department of Cardiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

出版信息

iScience. 2024 Jun 14;27(7):110275. doi: 10.1016/j.isci.2024.110275. eCollection 2024 Jul 19.

DOI:10.1016/j.isci.2024.110275
PMID:39040073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261152/
Abstract

Mitochondrial dysfunction has been known to contribute to the worsening of acute myocardial infarction (AMI). We screened differentially expressed genes (DEGs) between AMI and healthy individuals based on the GSE66360 dataset. We took the intersection of the obtained DEGs with 1,136 mitochondria-related genes. Finally, we screened out mitochondria-related DEGs (MitoDEGs). Eight MitoDEGs were identified as hub genes based on the random forest algorithm. Two mitochondria-related robust molecular clusters were identified by consensus clustering. Immune infiltration analysis showed that immune cell infiltration was significantly increased in the high-expression group of MitoDEGs. We obtained the potential drugs targeted at , , and , such as disulfiram, obatoclax mesylate, and bortezomib. Quantitative reverse-transcription polymerase chain reaction further validated the expression of the MitoDEGs in the cell model of AMI. These findings reveal the potential role of MitoDEGs in AMI and provide new insights into risk stratification and individualized treatment of AMI patients.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/f1a42ee7be6a/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/81597d2c957b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/702b2e16946d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/3bba9625080c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/e8abfaaea980/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/143d4a1da5c9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/a5c0ca139121/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/1ac941a26cc9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/d3dbae15fbf9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/fe5bea02ae8c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/c49bae8f5033/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/f1a42ee7be6a/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/81597d2c957b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/702b2e16946d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/3bba9625080c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/e8abfaaea980/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/143d4a1da5c9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/a5c0ca139121/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/1ac941a26cc9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/d3dbae15fbf9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/fe5bea02ae8c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/c49bae8f5033/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e0/11261152/f1a42ee7be6a/gr10.jpg

相似文献

[1]
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction.

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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation.

Mol Med Rep. 2025-9

[2]
Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction.

Sci Rep. 2025-7-1

[3]
Mitochondrial Dysfunction in Neurodegenerative Diseases.

Cells. 2025-2-13

本文引用的文献

[1]
Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives.

Cancer Biol Ther. 2023-12-31

[2]
Icariside II mitigates myocardial infarction by balancing mitochondrial dynamics and reducing oxidative stress through the activation of Nrf2/SIRT3 signaling pathway.

Eur J Pharmacol. 2023-10-5

[3]
Chemical screening links disulfiram with cardiac protection after ischemic injury.

Cell Regen. 2023-7-19

[4]
Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction.

Genes Immun. 2023-8

[5]
Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability.

J Control Release. 2023-8

[6]
Development and Validation of a Diagnostic Model Based on Hypoxia-Related Genes in Myocardial Infarction.

Int J Gen Med. 2023-5-29

[7]
Mitophagy in atherosclerosis: from mechanism to therapy.

Front Immunol. 2023

[8]
Identification of immune-related genes in acute myocardial infarction based on integrated bioinformatical methods and experimental verification.

PeerJ. 2023

[9]
Analysis of the influence of pyroptosis-related genes on molecular characteristics in patients with acute myocardial infarction.

Medicine (Baltimore). 2023-4-21

[10]
Hirsutine ameliorates myocardial ischemia-reperfusion injury through improving mitochondrial function via CaMKII pathway.

Clin Exp Hypertens. 2023-12-31

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