Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Cancer Biol Ther. 2023 Dec 31;24(1):2285817. doi: 10.1080/15384047.2023.2285817. Epub 2023 Nov 27.
The function of () in human cancer has not been thoroughly or comprehensively examined. Here, we identified the tumor suppressor part of across cancers, including epithelial ovarian tumors. Our study carefully contrasted the expression of VASH1 in pancancer and nontumorous tissues in a public database to explore its regulatory role in clinical prognosis, diagnosis, tumor purity, and immune cell infiltration. Next, we explored the antitumor mechanism of through drug sensitivity, functional enrichment, and phenotypic experiments in ovarian cancer. Research suggests that the expression of in neoplastic tissues is lower than that in normal tissues. affects the OS and RFS of several tumor types. In addition, expression resulted in a high OS and RFS in the diagnosis of tumor and nontumor tissues and negatively regulated tumor purity. Moreover, controls the tumor microenvironment by regulating immunocyte infiltration. In ovarian cancer, can serve as a biomarker to estimate the efficacy of chemotherapy. Functional enrichment analysis suggests that plays a tumor suppressor role by regulating the extracellular matrix receptor pathway. inhibition of the malignant phenotype of ovarian cancer cells was further confirmed by experiments. These results indicate that acts as a cancer-inhibiting factor and potential therapeutic target in ovarian cancer.
（）在人类癌症中的功能尚未得到彻底或全面的研究。在这里，我们确定了 across cancers 中肿瘤抑制因子的一部分，包括上皮性卵巢肿瘤。我们的研究仔细对比了公共数据库中泛癌和非肿瘤组织中 VASH1 的表达，以探讨其在临床预后、诊断、肿瘤纯度和免疫细胞浸润中的调节作用。接下来，我们通过卵巢癌中的药物敏感性、功能富集和表型实验探索了 的抗肿瘤机制。研究表明，在肿瘤组织中的表达低于在正常组织中的表达。 影响几种肿瘤类型的 OS 和 RFS。此外，在肿瘤和非肿瘤组织的诊断中， 的表达导致高 OS 和 RFS，并负调控肿瘤纯度。此外， 通过调节免疫细胞浸润来控制肿瘤微环境。在卵巢癌中， 可以作为评估化疗疗效的生物标志物。功能富集分析表明， 通过调节细胞外基质受体通路发挥肿瘤抑制作用。 通过实验进一步证实了 抑制卵巢癌细胞恶性表型的作用。这些结果表明， 在卵巢癌中作为一种抑癌因子和潜在的治疗靶点。
