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人体鼻腔内颗粒沉积的影响因素。

Influencing factors of particle deposition in the human nasal cavity.

作者信息

Guo Yingke, Tang Yuanyuan, Su Yingfeng, Sun Dong

机构信息

Department of Otolaryngology Head and Neck Surgery Second Affiliated Hospital of Dalian Medical University Dalian Liaoning Province China.

出版信息

Laryngoscope Investig Otolaryngol. 2024 Jul 22;9(4):e1308. doi: 10.1002/lio2.1308. eCollection 2024 Aug.

DOI:10.1002/lio2.1308
PMID:39040121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261810/
Abstract

OBJECTIVE

To review the existing literature on the application of computational fluid dynamics methods to study nasal particle deposition and to summarize and analyze the factors affecting nasal particle deposition in order to provide theoretical references for the development of future transnasal drug delivery devices and the prevention of respiratory-related diseases.

DATA SOURCE

PubMed and CNKI databases.

METHODS

A search of all current literature (up to and including February 2023) was conducted. Search terms related to the topic of factors influencing nasal particle deposition were identified, and queries were conducted to identify relevant articles.

RESULTS

Both the properties of the particles themselves and the environmental conditions external to the particles can affect particle deposition in the nasal cavity, with particle deposition showing a positive correlation with particle size, particle density, and airflow velocity, with increasing subject age leading to a decrease in deposition, and with the relationship between airflow temperature and humidity still requiring more research to further explore.

CONCLUSIONS

With the popularity of computational fluid dynamics, more and more scholars have applied computational fluid dynamics technology to explore the influence of different parameters on particle deposition. By summarizing and analyzing the influence law of various factors on deposition, it can provide a theoretical basis for the future development and application of transnasal drug delivery devices and the prevention of respiratory-related diseases, which makes a significant contribution to the optimization of clinical disease prevention and treatment.

LEVEL OF EVIDENCE

NA.

摘要

目的

回顾关于应用计算流体动力学方法研究鼻腔颗粒沉积的现有文献，总结并分析影响鼻腔颗粒沉积的因素，为未来经鼻给药装置的开发及呼吸道相关疾病的预防提供理论参考。

资料来源

PubMed和CNKI数据库。

方法

检索所有当前文献（截至2023年2月，包括2月）。确定与影响鼻腔颗粒沉积因素主题相关的检索词，并进行查询以识别相关文章。

结果

颗粒本身的性质以及颗粒外部的环境条件均可影响颗粒在鼻腔内的沉积，颗粒沉积与颗粒大小、颗粒密度和气流速度呈正相关，随着受试者年龄增长沉积减少，气流温度和湿度之间的关系仍需更多研究进一步探索。

结论

随着计算流体动力学的普及，越来越多的学者应用计算流体动力学技术探索不同参数对颗粒沉积的影响。通过总结和分析各种因素对沉积的影响规律，可为未来经鼻给药装置的开发应用及呼吸道相关疾病的预防提供理论依据，对优化临床疾病防治具有重要意义。

证据水平

无。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/36de2f9e3366/LIO2-9-e1308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/ee6cad3f561e/LIO2-9-e1308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/30f373da8bdf/LIO2-9-e1308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/c9c37f5fa59b/LIO2-9-e1308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/6c337e501ce7/LIO2-9-e1308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/ecda91ae7f67/LIO2-9-e1308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/36de2f9e3366/LIO2-9-e1308-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/ee6cad3f561e/LIO2-9-e1308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/30f373da8bdf/LIO2-9-e1308-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/c9c37f5fa59b/LIO2-9-e1308-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/6c337e501ce7/LIO2-9-e1308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/ecda91ae7f67/LIO2-9-e1308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf78/11261810/36de2f9e3366/LIO2-9-e1308-g005.jpg

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本文引用的文献

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Numerical and Machine Learning Analysis of the Parameters Affecting the Regionally Delivered Nasal Dose of Nano- and Micro-Sized Aerosolized Drugs.影响纳米和微米级雾化药物局部鼻腔给药剂量的参数的数值分析和机器学习分析
Pharmaceuticals (Basel). 2023 Jan 6;16(1):81. doi: 10.3390/ph16010081.
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Nasal vaccines: solutions for respiratory infectious diseases.
鼻用疫苗：应对呼吸道传染病的解决方案。
Trends Mol Med. 2023 Feb;29(2):124-140. doi: 10.1016/j.molmed.2022.10.009. Epub 2022 Nov 23.
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Detailed comparative analysis of environmental microparticle deposition characteristics between human and monkey nasal cavities using a surface mapping technique.采用表面映射技术对人体和猴鼻腔内环境微粒沉积特征进行详细比较分析。
Sci Total Environ. 2022 Dec 20;853:158770. doi: 10.1016/j.scitotenv.2022.158770. Epub 2022 Sep 13.
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Eur J Pharmacol. 2022 Mar 15;919:174821. doi: 10.1016/j.ejphar.2022.174821. Epub 2022 Feb 11.
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