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7T层流多对比度功能磁共振成像能够区分正性和负性BOLD反应背后的神经元兴奋和抑制。

Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.

作者信息

Shao Xingfeng, Guo Fanhua, Kim JungHwan, Ress David, Zhao Chenyang, Shou Qinyang, Jann Kay, Wang Danny Jj

机构信息

Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California.

Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston.

出版信息

medRxiv. 2024 Jul 12:2024.04.01.24305167. doi: 10.1101/2024.04.01.24305167.

DOI:10.1101/2024.04.01.24305167
PMID:39040201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11261924/
Abstract

A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive and negative BOLD responses. Here we present an innovative multi-contrast laminar functional MRI technique that offers comprehensive and quantitative imaging of neurovascular (CBF, CBV, BOLD) and metabolic (CMRO) responses across cortical layers at 7 Tesla. This technique was first validated through a finger-tapping experiment, revealing 'double-peak' laminar activation patterns within the primary motor cortex. By employing a ring-shaped visual stimulus that elicited positive and negative BOLD responses, we further observed distinct neurovascular and metabolic responses across cortical layers and eccentricities in the primary visual cortex. This suggests potential feedback inhibition of neuronal activities in both superficial and deep cortical layers underlying the negative BOLD signals in the fovea, and also illustrates the neuronal activities in visual areas adjacent to the activated eccentricities.

摘要

使用功能磁共振成像进行人类神经成像的一个主要挑战是区分可能诱导正性和负性BOLD反应的神经元兴奋和抑制。在此，我们展示了一种创新的多对比层流功能磁共振成像技术，该技术能够在7特斯拉磁场下对皮质各层的神经血管（CBF、CBV、BOLD）和代谢（CMRO）反应进行全面且定量的成像。该技术首先通过一项手指敲击实验得到验证，揭示了初级运动皮层内的“双峰”层流激活模式。通过采用一种能引发正性和负性BOLD反应的环形视觉刺激，我们进一步观察到初级视觉皮层各皮质层和不同偏心度区域存在明显的神经血管和代谢反应。这表明在中央凹负性BOLD信号下方的浅层和深层皮质层中，神经元活动可能存在潜在的反馈抑制，同时也说明了与激活的偏心度区域相邻的视觉区域的神经元活动情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/5661c7dd5433/nihpp-2024.04.01.24305167v2-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/48a223f3bd8f/nihpp-2024.04.01.24305167v2-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/5dc37c260f43/nihpp-2024.04.01.24305167v2-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/592ecbf4cfa2/nihpp-2024.04.01.24305167v2-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/17140396beda/nihpp-2024.04.01.24305167v2-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/74853c96ef2b/nihpp-2024.04.01.24305167v2-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/7e065f2d45d9/nihpp-2024.04.01.24305167v2-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/cdd99261c269/nihpp-2024.04.01.24305167v2-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/5661c7dd5433/nihpp-2024.04.01.24305167v2-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/48a223f3bd8f/nihpp-2024.04.01.24305167v2-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/5dc37c260f43/nihpp-2024.04.01.24305167v2-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/592ecbf4cfa2/nihpp-2024.04.01.24305167v2-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/17140396beda/nihpp-2024.04.01.24305167v2-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/74853c96ef2b/nihpp-2024.04.01.24305167v2-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/7e065f2d45d9/nihpp-2024.04.01.24305167v2-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/cdd99261c269/nihpp-2024.04.01.24305167v2-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6988/11261924/5661c7dd5433/nihpp-2024.04.01.24305167v2-f0008.jpg

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