Zhang Long, Li Jing-Yu, Xu Shi-Qiang, Wang Ji-Hua
Key Laboratory of Crop Genetic Improvement of Guangdong Province, Crops Research Institute, Guangdong Academy of Agricultural Sciences Guangzhou 510640, China Guangdong Provincial Engineering and Technology Research Center for Conservation and Utilization of the Genuine Southern Medicinal Resources Guangzhou 510640, China College of Plant Science and Technology, Huazhong Agricultural University Wuhan 430070, China.
Key Laboratory of Crop Genetic Improvement of Guangdong Province, Crops Research Institute, Guangdong Academy of Agricultural Sciences Guangzhou 510640, China Guangdong Provincial Engineering and Technology Research Center for Conservation and Utilization of the Genuine Southern Medicinal Resources Guangzhou 510640, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jul;49(13):3432-3440. doi: 10.19540/j.cnki.cjcmm.20240412.101.
Molecular pharmacognosy as an emerging interdisciplinary subject based on molecular biology and Chinese materia medica aims to study the synthesis and molecular regulation of secondary metabolites in medicinal plants. Andrographis Herba, the dried aboveground part of Andrographis paniculata, has liver-protecting, bile secretion-promoting, heat-clearing, toxin-removing, antimicrobial, and anti-inflammatory effects. The quality instability caused by plant varieties, environment, and technology in the production of A. paniculata is a limiting factor for the sustainable development of this industry. Based on the research methods of molecular pharmacognosy and omics, the regulation of secondary metabolites of A. paniculata has become the key solution to the quality problems of A. paniculata. This paper summarized the recent research achievements in the molecular pharmacognosy of A. paniculata, including molecular identification of the resources, genetic diversity, multi-omics, biosynthesis of active compounds, and germplasm resource innovation, and prospected the future development trend in this field. In-depth research of molecular pharmacognosy of A. paniculata will provide more scientific and effective technical support for the development of its medicinal value, give new insights into the cultivation of new A. paniculata varieties, and promote the high-quality sustainable development of this industry.
分子生药学作为一门基于分子生物学和中药学的新兴交叉学科，旨在研究药用植物中次生代谢产物的合成及其分子调控。穿心莲为爵床科植物穿心莲干燥地上部分，具有保肝、利胆、清热、解毒、抗菌、抗炎等作用。穿心莲生产过程中因植物品种、环境及技术等因素导致的质量不稳定是该产业可持续发展的制约因素。基于分子生药学和组学的研究方法，穿心莲次生代谢产物的调控已成为解决穿心莲质量问题的关键。本文综述了穿心莲分子生药学的研究进展，包括资源分子鉴定、遗传多样性、多组学、活性成分生物合成及种质资源创新等方面，并对该领域未来的发展趋势进行了展望。深入开展穿心莲分子生药学研究，将为其药用价值开发提供更加科学有效的技术支撑，为穿心莲新品种培育提供新的思路，推动该产业高质量可持续发展。
