Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Future Cardiol. 2024;20(10):547-554. doi: 10.1080/14796678.2024.2377924. Epub 2024 Jul 23.
To explore potential value of inter-alpha-trypsin inhibitor heavy chain-4 (ITIH4) for coronary artery disease (CAD) diagnosis. We recruited the patients who received coronary arteriography (CAG) examination. The enzyme-linked immunosorbent assay was used to detect plasma ITIH4. ITIH4 level was lower expression in CAD patients than that in patients of control group, and was negatively correlated with C-reactive protein (CRP). ITIH4 level is no differences between ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients. However, its expression was significantly correlated with D-Dimer and thrombin time, and the logistic analysis confirmed predictive value of ITIH4 for visible thrombus in coronary. ITIH4 may be a useful biomarker in CAD diagnosis, and to predict visible thrombus in coronary.
探讨α-胰蛋白酶抑制剂重链 4（ITIH4）在冠状动脉疾病（CAD）诊断中的潜在价值。我们招募了接受冠状动脉造影（CAG）检查的患者。采用酶联免疫吸附试验检测血浆 ITIH4。CAD 患者的 ITIH4 水平低于对照组，且与 C 反应蛋白（CRP）呈负相关。STEMI 与 NSTEMI 患者的 ITIH4 水平无差异。然而，其表达与 D-二聚体和凝血酶时间显著相关，逻辑分析证实 ITIH4 对冠状动脉可见血栓具有预测价值。ITIH4 可能是 CAD 诊断和预测冠状动脉可见血栓的有用生物标志物。
