Department of Surgery, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou 310058, China.
Future Oncol. 2024;20(25):1851-1860. doi: 10.1080/14796694.2024.2370236. Epub 2024 Jul 23.
Malignant tumors including gastric cancer (GC) are the leading cause of deaths among reproductive women. Physiological morning sickness can mask the clinical manifestations of GC, whereas the clinical presence of metastatic tumors in the abdominal cavity may be easily mistaken for abdominal swelling caused by fetal growth. Pregnancy and delivery processes in young females could accelerate the growth of GC, leading to its rapid development and grave prognosis. Therefore, early diagnosis is critical and gastrointestinal endoscopy is recommended for any suspected pregnant woman with long-term morning sickness. Treatment strategies, including chemotherapy, resection surgery and radiotherapy, will be determined based on a comprehensive consideration of the status of both the fetus and the mother. Rational management, especially clinical multidisciplinary collaboration may significantly benefit such patients.
恶性肿瘤包括胃癌（GC）是生育期女性死亡的主要原因。妊娠生理性晨吐可能会掩盖 GC 的临床表现，而腹腔转移性肿瘤的临床存在可能很容易被误认为是胎儿生长引起的腹胀。年轻女性的妊娠和分娩过程可能会加速 GC 的生长，导致其快速发展和预后不良。因此，早期诊断至关重要，建议对有长期晨吐症状的疑似孕妇进行胃肠镜检查。治疗策略包括化疗、手术切除和放疗，将根据胎儿和母亲的状况综合考虑来确定。合理的管理，特别是临床多学科合作，可能会使这些患者显著受益。
