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颈椎损伤流行病学的变化趋势:对国家电子伤害监测系统中20年间11822例患者的分析。

Shifting Trends in the Epidemiology of Cervical Spine Injuries: An Analysis of 11,822 Patients from the National Electronic Injury Surveillance System over Two Decades.

作者信息

Futch Brittany Grace, Seas Andreas, Ononogbu-Uche Favour, Khedr Shahenda, Kreinbrook Judah, Shaffrey Christopher I, Williamson Theresa, Guest James David, Fehlings Michael G, Abd-El-Barr Muhammad M, Foster Norah A

机构信息

Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.

Department of Biomedical Engineering, Duke University Pratt School of Engineering, Durham, North Carolina, USA.

出版信息

J Neurotrauma. 2024 Sep;41(17-18):2158-2167. doi: 10.1089/neu.2024.0194. Epub 2024 Aug 2.

Abstract

Cervical spine injuries (CSIs) are heterogeneous in nature and often lead to long-term disability and morbidity. However, there are few recent and comprehensive epidemiological studies on CSI. The objective of this study was to characterize recent trends in CSI patient demographics, incidence, etiology, and injury level. The National Electronic Injury Surveillance System was used to extract data on CSIs from 2002 to 2022. Weighted national estimates of CSI incidence were computed using yearly population estimates interpolated from U.S. census data. Data analysis involved extracting additional information from patient narratives to categorize injury etiology (i.e., fall) and identify CSI level. K-means clustering was performed on cervical levels to define upper versus lower cervical injuries. Appropriate summary statistics including mean with 95% confidence intervals and frequency were reported for age, sex, race, ethnicity, etiology, and disposition. Age between groups was compared using an independent weighted -test. All categorical variables were compared using Pearson chi-squared tests with Bonferroni correction for multiple comparisons. Ordinary least squares linear regression was used to quantify the rate of change of various metrics with time. A total of 11,822 patient records met the study criteria. The mean age of patients was 62.4 ± 22.7 years, 52.4% of whom were male and 61.4% of whom were White, 7.4% were Black, 27.8% were not specified, and the remaining comprised a variety of ethnicities. The most common mechanism of CSI was a fall (67.3%). There was a significant increase in the incidence of cervical injuries between 2003 and 2022 ( < 0.001). Unbiased K-means clustering defined upper cervical injuries as C1-C3 and lower cervical injuries as C4-C7. The mean age of patients with upper CSIs was 72.3 ± 19.6, significantly greater than the age of those with lower CSIs (57.1 ± 23.1, < 0.001). Compared with lower CSI, White patients were more likely to have an upper CSI (67.4% vs. 73.7%; < 0.001). While Black/African American (7.5% vs. 3.8%) and Hispanic (2.5% vs. 1.0%) patients were more likely to have a lower CSI ( < 0.001). Our study identified a significant increase in the incidence of CSIs over time, which was associated with increasing patient age. Our study detected a pragmatic demarcation of classifying upper injuries as C1-C3 and lower cervical injuries as C4-C7. Upper injuries were seen more often in older, White females who were treated and admitted, and lower injuries were seen more often in young, Black male patients who were released without admission.

摘要

颈椎损伤(CSIs)本质上具有异质性,常导致长期残疾和发病。然而,近期关于颈椎损伤的全面流行病学研究较少。本研究的目的是描述颈椎损伤患者人口统计学、发病率、病因和损伤水平的近期趋势。使用国家电子伤害监测系统提取2002年至2022年期间颈椎损伤的数据。利用从美国人口普查数据插值得到的年度人口估计数计算颈椎损伤发病率的加权全国估计值。数据分析包括从患者叙述中提取额外信息,以对损伤病因(即跌倒)进行分类并确定颈椎损伤水平。对颈椎水平进行K均值聚类,以定义上颈椎损伤与下颈椎损伤。报告了年龄、性别、种族、族裔、病因和处置情况的适当汇总统计数据,包括均值及其95%置信区间和频率。使用独立加权t检验比较组间年龄。所有分类变量均使用Pearson卡方检验,并采用Bonferroni校正进行多重比较。使用普通最小二乘线性回归来量化各种指标随时间的变化率。共有11822份患者记录符合研究标准。患者的平均年龄为62.4±22.7岁;其中52.4%为男性,61.4%为白人,7.4%为黑人,27.8%未明确说明,其余包括各种族裔。颈椎损伤最常见的机制是跌倒(67.3%)。2003年至2022年期间颈椎损伤的发病率显著增加(P<0.001)。无偏K均值聚类将上颈椎损伤定义为C1-C3,下颈椎损伤定义为C4-C7。上颈椎损伤患者的平均年龄为72.3±19.6岁,显著高于下颈椎损伤患者的年龄(57.1±23.1岁,P<0.001)。与下颈椎损伤相比,白人患者更易发生上颈椎损伤(67.4%对73.7%;P<0.001)。而黑人/非裔美国人(7.5%对3.8%)和西班牙裔(2.5%对1.0%)患者更易发生下颈椎损伤(P<0.001)。我们的研究发现,随着时间推移颈椎损伤的发病率显著增加,这与患者年龄增加有关。我们的研究发现将上颈椎损伤分类为C1-C3、下颈椎损伤分类为C4-C7是一种实用的划分方法。上颈椎损伤在接受治疗并入院的老年白人女性中更常见,而下颈椎损伤在未入院即出院的年轻黑人男性患者中更常见。

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