Zhu Shijie, Tian Xue, Li Shi-Wu
School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, Shihezi University, Shihezi, Xinjiang 832003, People's Republic of China.
Org Lett. 2024 Aug 2;26(30):6309-6313. doi: 10.1021/acs.orglett.4c01512. Epub 2024 Jul 23.
Silyl enol ethers react with bicyclo[1.1.0]butanes (BCBs) through Yb(OTf)-promoted formal [2π + 2σ] cycloaddition reactions to furnish bicyclo[2.1.1]hexanes (BCHs). This new reaction tolerated a wide range of enol silyl ethers and BCBs. Furthermore, the amplification experiments and synthetic transformations of the cycloaddition compounds further highlighted their practicality.
硅烯醇醚通过Yb(OTf)促进的形式上的[2π + 2σ]环加成反应与双环[1.1.0]丁烷（BCBs）反应，生成双环[2.1.1]己烷（BCHs）。这种新反应能耐受多种烯醇硅醚和BCBs。此外，环加成化合物的放大实验和合成转化进一步突出了它们的实用性。
