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麻疹是怎么回事?

What's going on with measles?

机构信息

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

出版信息

J Virol. 2024 Aug 20;98(8):e0075824. doi: 10.1128/jvi.00758-24. Epub 2024 Jul 23.

Abstract

Measles is a highly transmissible systemic viral infection associated with substantial mortality primarily due to secondary infections. Measles induces lifelong immunity to reinfection but loss of immunity to other pathogens. An attenuated live virus vaccine is highly effective, but lapses in delivery have resulted in increasing cases worldwide. Although the primary cause of failure to control measles is failure to vaccinate, waning vaccine-induced immunity and the possible emergence of more virulent virus strains may also contribute.

摘要

麻疹是一种高度传染性的全身病毒性感染,主要由于继发感染导致死亡率较高。麻疹可诱导终身对再感染的免疫力,但会丧失对其他病原体的免疫力。减毒活病毒疫苗非常有效,但由于疫苗接种的中断,导致全球麻疹病例不断增加。尽管未能控制麻疹的主要原因是未能接种疫苗,但疫苗诱导的免疫力下降以及可能出现更具毒性的病毒株也可能有影响。

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