Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Immunol Invest. 2024 Oct;53(7):1013-1029. doi: 10.1080/08820139.2024.2382792. Epub 2024 Jul 23.
Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving a variety of immune cells such as mast cells. In previous studies, AR was considered as an isolated disease of the immune system. However, recent studies have found that the nervous system is closely related to the development of AR. Bidirectional communication between the nervous and immune systems plays an important role in AR.
The nervous system and immune system depend on the anatomical relationship between nerve fibers and immune cells, as well as various neurotransmitters, cytokines, inflammatory mediators, etc. to produce bidirectional connections, which affect the development of AR.
This article reviews the impact of neuro-immune interactions in AR on the development of AR, including neuro-immune cell units.
变应性鼻炎（AR）是一种由 IgE 介导的非传染性鼻黏膜炎症性疾病，涉及多种免疫细胞，如肥大细胞。在以往的研究中，AR 被认为是一种孤立的免疫系统疾病。然而，最近的研究发现，神经系统与 AR 的发生密切相关。神经系统和免疫系统之间的双向交流在 AR 中起着重要作用。
神经系统和免疫系统依赖于神经纤维和免疫细胞之间的解剖关系，以及各种神经递质、细胞因子、炎症介质等，从而产生双向连接，影响 AR 的发展。
本文综述了 AR 中的神经-免疫相互作用对 AR 发展的影响，包括神经-免疫细胞单元。
