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绝经后会出现尿动力学压力性尿失禁吗?:澳大利亚女性 2994 项尿动力学研究结果。

Does Urodynamic Stress Incontinence Increase After the Menopause?: Results from 2,994 Urodynamic Studies in Australian Women.

机构信息

St George Hospital, School of Women's and Children's Health, University of New South Wales, Sydney, Kogarah, Australia.

The George Institute for Global Health, University of New South Wales, Sydney, Australia.

出版信息

Int Urogynecol J. 2024 Sep;35(9):1789-1796. doi: 10.1007/s00192-024-05876-3. Epub 2024 Jul 23.

Abstract

INTRODUCTION AND HYPOTHESIS

Most studies attempting to estimate the age-related prevalence of urinary incontinence (UI) have used questionnaires. In the present study we analysed a consecutive series of urodynamic test results to determine the distribution of the different types of UI in pre- and post-menopausal women. We hypothesised that the prevalence of urodynamic stress incontinence (USI) would be significantly greater in pre-menopausal than in post-menopausal women.

METHODS

All women from a large tertiary urogynaecology department, who underwent urodynamic tests during the years 2000-2015 were included. Patient history and test results were collected. A sample size of 1,475 was calculated, based on the hypothesis that the prevalence of USI will be 20% larger in the pre- versus the post-menopausal group.

RESULTS

A total of 2,994 women with UI on urodynamics were available. There was a significant difference between pre- and post-menopausal status for each of the three diagnoses: USI 483 (59.3%) versus 912 (41.8%), detrusor overactivity (DO) 125 (15.4%) versus 399 (18.3%) and USI with concomitant DO 206 (25.3%) versus 869 (39.9%). A bimodal pattern of age was seen in women with USI, with a peak in the 46-50 and 61-65 age group, before decreasing with age. DO generally increased with age. USI with concomitant DO increased steadily after the menopause, becoming the predominant type after the age of 66.

CONCLUSIONS

In this large cohort of women attending urodynamics, we have shown that USI is the predominant type of incontinence in pre-menopausal women; however, USI with concomitant DO increases after menopause, eventually predominating.

摘要

简介与假设

大多数试图估计尿失禁(UI)与年龄相关的患病率的研究都使用了问卷。在本研究中,我们分析了一系列连续的尿动力学测试结果,以确定绝经前和绝经后妇女不同类型 UI 的分布。我们假设在绝经前女性中,尿动力学压力性尿失禁(USI)的患病率显著高于绝经后女性。

方法

纳入 2000 年至 2015 年间在一家大型泌尿科妇科接受尿动力学检查的所有女性。收集患者病史和检查结果。根据 USI 在绝经前组中的患病率将比绝经后组大 20%的假设,计算出 1475 名患者的样本量。

结果

共有 2994 名女性在尿动力学检查中出现 UI。三种诊断中,绝经前和绝经后状态之间存在显著差异:USI 483 例(59.3%)与 912 例(41.8%)、逼尿肌过度活动(DO)125 例(15.4%)与 399 例(18.3%)和 USI 合并 DO 206 例(25.3%)与 869 例(39.9%)。USI 女性的年龄呈双峰模式,46-50 岁和 61-65 岁年龄段达到峰值,然后随年龄下降。DO 通常随年龄增加而增加。USI 合并 DO 绝经后逐渐增加,66 岁后成为主要类型。

结论

在本项参加尿动力学检查的大量女性队列中,我们发现 USI 是绝经前女性中主要的失禁类型;然而,绝经后 USI 合并 DO 逐渐增加,最终成为主要类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/632a/11420294/fdff66ff7026/192_2024_5876_Fig1_HTML.jpg

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