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富血小板纤维蛋白增强鼓室成形术与软骨鼓室成形术的比较：一项随机临床试验。

Platelet rich fibrin augmented tympanoplasty versus cartilage tympanoplasty: a randomized clinical trial.

机构信息

Department of Otorhinolaryngology, Mansoura University, Mansoura, 35511, Egypt.

出版信息

Eur Arch Otorhinolaryngol. 2024 Nov;281(11):5739-5746. doi: 10.1007/s00405-024-08819-2. Epub 2024 Jul 23.

DOI:10.1007/s00405-024-08819-2
PMID:39042174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11512834/
Abstract

OBJECTIVES

The aim of the current study was to evaluate the efficacy of PRF-augmented fascia tympanoplasty versus cartilage tympanoplasty in repair of large TM perforations.

METHODS

This randomized clinical trial included 156 patients with dry large tympanic membrane perforations. Patients were randomly allocated into 2 groups, cartilage tympanoplasty group (n = 77) and platelet rich fibrin (PRF) augmented tympanoplasty group (n = 79). Graft take rates, hearing outcomes, operative time, and postoperative complications were documented and compared.

RESULTS

Graft take rate was 96.1% in the cartilage group and 93.7% PRF group with no statistically significant difference. Operative time was significantly longer in the cartilage group. No differences in the hearing outcomes and postoperative complications were reported.

CONCLUSION

Application of PRF on the fascia in tympanoplasty promotes healing of the tympanic membrane. PRF is safe, cheap, readily available, and easily prepared and applied. It increases the success rates of large tympanic membrane perforations without the need for cartilage grafts.

摘要

目的

本研究旨在评估富血小板纤维蛋白（PRF）增强鼓膜成形术与软骨鼓膜成形术治疗大鼓膜穿孔的疗效。

方法

本随机临床试验纳入了 156 例干燥性大鼓膜穿孔患者。患者被随机分为两组，软骨鼓膜成形术组（n=77）和富含血小板纤维蛋白（PRF）增强鼓膜成形术组（n=79）。记录并比较移植物成活率、听力结果、手术时间和术后并发症。

结果

软骨组的移植物成活率为 96.1%，PRF 组为 93.7%，差异无统计学意义。软骨组的手术时间明显较长。两组听力结果和术后并发症无差异。

结论

PRF 在鼓膜成形术中应用于鼓膜筋膜可促进鼓膜愈合。PRF 安全、廉价、易于获得，且易于制备和应用。它可以提高大鼓膜穿孔的成功率，而无需软骨移植物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/d8d3631b0225/405_2024_8819_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/62c8bf63113c/405_2024_8819_Figc_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/8f2b25b2f2a0/405_2024_8819_Figd_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/366fedc76b80/405_2024_8819_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/d8d3631b0225/405_2024_8819_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/62c8bf63113c/405_2024_8819_Figc_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/8f2b25b2f2a0/405_2024_8819_Figd_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/366fedc76b80/405_2024_8819_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1340/11512834/d8d3631b0225/405_2024_8819_Figb_HTML.jpg

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