El-Anwar Mohammad Waheed, Elnashar Ismail, Foad Yaser Ahmad
Department of Otolaryngology-Head and Neck Surgery, Zagazig University Faculty of Medicine, Zagazig, Egypt.
Ear Nose Throat J. 2017 Aug;96(8):312-326. doi: 10.1177/014556131709600818.
We conducted a prospective study to assess the effectiveness of a platelet-rich plasma hourglass graft in the repair of small tympanic membrane perforations as an office-based procedure. Our study population was made up of 25 patients-10 men and 15 women, aged 19 to 45 years (mean: 30.4 ± 7.2)-who each underwent repair of one eardrum. After administration of topical anesthesia, a single piece of platelet-rich plasma approximately double the size of the perforation was obtained from each patient's intravenous blood sample. After the margin of the perforation was freshened, the platelet-rich plasma was placed in an hourglass configuration, with equal portions lying medial and lateral to the perforation. Successful perforation repair was achieved in 21 of the 25 ears (84%). No patient developed an infection, hearing impairment, tinnitus, vertigo, bleeding, taste disturbance, or hyperkeratosis. We conclude that office-based platelet-rich plasma myringoplasty is a safe and effective minimally invasive procedure that is suitable for repairing small tympanic membrane perforations.
我们进行了一项前瞻性研究，以评估富血小板血浆沙漏形移植物作为一种门诊手术在修复小鼓膜穿孔方面的有效性。我们的研究对象包括25名患者，其中10名男性和15名女性，年龄在19至45岁之间（平均年龄：30.4±7.2岁），他们每人都接受了一次鼓膜修复手术。在局部麻醉后，从每位患者的静脉血样本中获取一片面积约为穿孔两倍大小的富血小板血浆。在将穿孔边缘清理新鲜后，将富血小板血浆呈沙漏形放置，使穿孔内侧和外侧的部分相等。25只耳朵中有21只（84%）成功实现了穿孔修复。没有患者出现感染、听力障碍、耳鸣、眩晕、出血、味觉障碍或角化过度。我们得出结论，门诊富血小板血浆鼓膜成形术是一种安全有效的微创手术，适用于修复小鼓膜穿孔。
