Varma R, Hoshino A Y
Neurosci Lett. 1979 Mar;11(3):353-6. doi: 10.1016/0304-3940(79)90021-1.
A simple, rapid and precise gas-chromatographic procedure which involves one-step extraction and on-column methylation for routine clinical monitoring of plasma valproic acid levels is described. Six other commonly, simultaneously administered anticonvulsants can also be determined by substituting methylene chloride for chloroform for extraction and changing the column temperature. Also, described is the effect of valproic acid on blood levels of other simultaneously administered anticonvulsants.
本文描述了一种简单、快速且精确的气相色谱法，该方法涉及一步萃取和柱上甲基化，用于血浆丙戊酸水平的常规临床监测。通过用二氯甲烷代替氯仿进行萃取并改变柱温，还可同时测定其他六种常用的同时给药的抗惊厥药。此外，还描述了丙戊酸对其他同时给药的抗惊厥药血药浓度的影响。
