Riva R, Albani F, Baruzzi A
J Pharm Sci. 1982 Jan;71(1):110-1. doi: 10.1002/jps.2600710126.
A GLC method for the determination of valproic acid and ethosuximide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GLC injection of the unconcentrated organic phase. This rapid, sensitive, specific, and reproducible method has been used for 2 years for the routine determination of plasma levels of valproic acid and ethosuximide in epileptic patients who receive other antiepileptic drugs simultaneously.
建立了一种用于测定血浆中丙戊酸和乙琥胺的气相色谱法。该方法包括从酸化的血浆样品中用单一溶剂萃取药物，然后对未浓缩的有机相进行气相色谱进样。这种快速、灵敏、特异且可重复的方法已用于同时接受其他抗癫痫药物治疗的癫痫患者血浆中丙戊酸和乙琥胺水平的常规测定达两年之久。
