Instituto de Ensino, Pesquisa e Inovação. Liga Contra o Câncer, Natal, Rio Grande do Norte, Brazil.
Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
PLoS One. 2024 Jul 23;19(7):e0306623. doi: 10.1371/journal.pone.0306623. eCollection 2024.
Obesity is a silent pandemic affecting all ages and is a component of metabolic syndrome. Its treatment is conducted by lifestyle and behavioral changes, pharmacological therapy, and when correctly indicated, bariatric surgery. In recent years, the procedures for weight loss have been investigated due to their relationship with the development of many types of cancer. Although many studies have shown that bariatric surgery decreases cancer risk, other researchers observed an increase in this association. Carcinogenesis is affected by many factors, such as age, sex, type of cancer, and the bariatric surgery performed on each patient. This systematic review and meta-analysis protocol aims to clarify the association between the different modalities of bariatric surgery and the risk of cancer development in adult patients with metabolic syndrome.
The proposed systematic review and meta-analysis will be reported conforming to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-P) guidelines. This research will include observational studies (case-control and cohort studies) about patients who undergo bariatric surgery due to metabolic syndrome. Will be accepted in any language and any year. Publications without peer review will be excluded from this review. Data will be entered into the Review Manager software (RevMan5.2.3). We extracted or calculated the OR and 95% CI for dichotomous outcomes for each study. In case of heterogeneity (I2>50%), the random-effects model will combine the studies to calculate the OR and 95% CI.
This study will review the published data; Thus, obtaining ethical approval is unnecessary. The findings of this systematic review will be published in a peer-reviewed journal.
CRD42023432079.
肥胖是一种影响所有年龄段的无声流行疾病，也是代谢综合征的组成部分。其治疗方法包括生活方式和行为改变、药物治疗以及在适当情况下进行减肥手术。近年来，由于减肥手术与许多类型癌症的发生有关，因此对其减肥效果进行了研究。尽管许多研究表明减肥手术可以降低癌症风险，但其他研究人员观察到这种关联有所增加。癌症的发生受到许多因素的影响，例如年龄、性别、癌症类型以及每位患者接受的减肥手术类型。本系统评价和荟萃分析方案旨在阐明不同减肥手术方式与代谢综合征成年患者癌症发展风险之间的关联。
拟议的系统评价和荟萃分析将按照系统评价和荟萃分析的首选报告项目（PRISMA-P）指南进行报告。本研究将包括关于因代谢综合征而接受减肥手术的患者的观察性研究（病例对照和队列研究）。将接受任何语言和任何年份的研究。没有同行评审的出版物将被排除在本综述之外。数据将输入 Review Manager 软件（RevMan5.2.3）。我们从每项研究中提取或计算了二分类结果的 OR 和 95%CI。如果存在异质性（I2>50%），则将使用随机效应模型对研究进行合并，以计算 OR 和 95%CI。
本研究将回顾已发表的数据；因此，获得伦理批准是不必要的。本系统评价的研究结果将发表在同行评议的期刊上。
PROSPERO 注册号：CRD42023432079。
