From the Department of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Cancer J. 2024;30(4):227-231. doi: 10.1097/PPO.0000000000000725.
In locally advanced rectal cancer, neoadjuvant treatment has evolved from no preoperative treatment to the addition of radiation and systemic therapy and ultimately total neoadjuvant therapy. Total neoadjuvant therapy is the completion of preoperative radiation or chemoradiation and chemotherapy before surgery in order to maximize tumor response and improve survival outcomes. This review summarizes the literature of the neoadjuvant approaches related to locally advanced rectal cancer and highlights the nuances of selecting the appropriate treatment.
在局部进展期直肠癌中，新辅助治疗已经从术前不治疗演变为加用放疗和系统治疗，最终演变为完全新辅助治疗。完全新辅助治疗是指在手术前完成术前放疗或放化疗和化疗，以最大限度地提高肿瘤反应，改善生存结局。本综述总结了局部进展期直肠癌新辅助治疗方法的文献，并强调了选择合适治疗方法的细微差别。
