Department of Intensive Care Medicine, Ganzhou People's Hospital, Ganzhou City, Jiangxi Province, China.
Department of Respiratory and Critical Care Medicine, Ganzhou Fifth People's Hospital, Ganzhou City, Jiangxi Province, China.
Libyan J Med. 2024 Dec 31;19(1):2383025. doi: 10.1080/19932820.2024.2383025. Epub 2024 Jul 23.
To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of the patient's condition, they were separated into sepsis group ( = 76), severe sepsis group ( = 59), and sepsis shock group ( = 45). Based on the survival within 28 days of admission, they were grouped into survivors group ( = 128) and nonsurvivors group ( = 52). The serum Midkine level and APACHE II score in the sepsis shock group were higher than those in the severe sepsis group and sepsis group, while the Omentin-1 level was lower than that in the severe sepsis group and sepsis group ( < 0.05). The serum Midkine level and APACHE II score in the severe sepsis group were higher than those in the sepsis group, while the Omentin-1 level was lower than that in the sepsis group ( < 0.05). The Midkine and APACHE II score in the nonsurvivors group was higher than those in the survivors group, while the Omentin-1 score was lower than that in the survivors group ( < 0.05). Midkine and APACHE II score were independent risk factors for the prognosis of sepsis patients, while Omentin-1 was a protective factor for the prognosis of sepsis patients ( < 0.05). The AUC of the combined prediction of serum Midkine and Ommentin-1 for the prognosis of sepsis patients was 0.880, with a sensitivity of 90.38% and a specificity of 72.66%. The combined prediction of serum Midkine and Ommentin-1 was better than that of individual prediction of Midkine and Ommentin-1. Serum Midkine is highly expressed and Omentin-1 is lowly expressed in sepsis patients, and the combination of the two has a high predictive power for the prognosis of sepsis patients.
探讨血清中期因子（Midkine）和网膜素-1（Omentin-1）与脓毒症患者病情严重程度的关系及其预后价值。对 180 例脓毒症患者的临床资料进行回顾性分析。根据患者病情严重程度，分为脓毒症组（n=76）、严重脓毒症组（n=59）和脓毒症休克组（n=45）。根据入院 28 天内的生存情况，分为存活组（n=128）和死亡组（n=52）。脓毒症休克组血清 Midkine 水平和急性生理与慢性健康状况评分系统Ⅱ（APACHE Ⅱ）评分均高于严重脓毒症组和脓毒症组，而 Omentin-1 水平低于严重脓毒症组和脓毒症组（均 P<0.05）。严重脓毒症组血清 Midkine 水平和 APACHE Ⅱ评分均高于脓毒症组，而 Omentin-1 水平低于脓毒症组（均 P<0.05）。死亡组 Midkine 和 APACHE Ⅱ评分均高于存活组，而 Omentin-1 评分低于存活组（均 P<0.05）。Midkine 和 APACHE Ⅱ评分是脓毒症患者预后的独立危险因素，而 Omentin-1 是脓毒症患者预后的保护因素（均 P<0.05）。血清 Midkine 和 Ommentin-1 联合预测脓毒症患者预后的 AUC 为 0.880，敏感度为 90.38%，特异度为 72.66%。血清 Midkine 和 Ommentin-1 联合预测优于单独预测。脓毒症患者血清 Midkine 高表达，Omentin-1 低表达，两者联合对脓毒症患者预后具有较高的预测价值。
