Biegański Hubert Mateusz, Dąbrowski Krzysztof Maksymilian, Różańska-Walędziak Anna
Medical Faculty, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland.
Departament of Human Physiology and Pathophysiology, Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland.
Biomedicines. 2025 Mar 5;13(3):632. doi: 10.3390/biomedicines13030632.
Omentin (omentin-1, intelectin-1, ITLN-1) is an adipokine considered to be a novel substance. Many chronic, inflammatory, or civilization diseases are linked to obesity, in which omentin plays a significant role. : MEDLINE and SCOPUS databases were searched using the keywords "omentin" or "intelectin-1". Then the most recent articles providing new perspectives on the matter and the most important studies, which revealed crucial insight, were selected to summarize the current knowledge on the role of omentin in a literature review. : The valid role of this adipokine is evident in the course of metabolic syndrome. In most cases, elevated omentin expression is correlated with the better course of diseases, including: type 2 diabetes mellitus, polycystic ovary syndrome, rheumatoid arthritis, metabolic dysfunction-associated steatotic liver disease, Crohn's disease, ulcerative colitis, atherosclerosis, or ischemic stroke, for some of which it can be a better marker than the currently used ones. However, results of omentin studies are not completely one-sided. It was proven to participate in the development of asthma and atopic dermatitis and to have different concentration dynamics in various types of tumors. All of omentin's effects and properties make it an attractive subject of research, considering still unexplored inflammation mechanisms, in which it may play an important role. Omentin was proven to prevent osteoarthritis, hepatocirrhosis, and atherosclerosis in mouse models. All of the above places omentin among potential therapeutic products, and not only as a biomarker. However, the main problems with the omentin's research state are the lack of standardization, which causes many contradictions and disagreements in this field.
网膜素（网膜素-1、肝免疫凝集素-1、ITLN-1）是一种被认为是新型物质的脂肪因子。许多慢性、炎症性或文明病都与肥胖有关，网膜素在其中起着重要作用。：使用关键词“网膜素”或“肝免疫凝集素-1”检索MEDLINE和SCOPUS数据库。然后选择提供该问题新观点的最新文章以及揭示关键见解的最重要研究，在文献综述中总结关于网膜素作用的当前知识。：这种脂肪因子在代谢综合征过程中的有效作用是明显的。在大多数情况下，网膜素表达升高与疾病的较好病程相关，包括：2型糖尿病、多囊卵巢综合征、类风湿性关节炎、代谢功能障碍相关脂肪性肝病、克罗恩病、溃疡性结肠炎、动脉粥样硬化或缺血性中风，其中一些疾病中它可能是比目前使用的指标更好的标志物。然而，网膜素的研究结果并非完全片面。已证明它参与哮喘和特应性皮炎的发展，并且在各种类型的肿瘤中具有不同的浓度动态。考虑到仍未探索的炎症机制，网膜素可能在其中发挥重要作用，其所有作用和特性使其成为一个有吸引力的研究对象。在小鼠模型中已证明网膜素可预防骨关节炎、肝硬化和动脉粥样硬化。上述所有情况使网膜素跻身于潜在治疗产品之列，而不仅仅是作为一种生物标志物。然而，网膜素研究现状的主要问题是缺乏标准化，这在该领域导致了许多矛盾和分歧。
