Department of General Surgery, Faculty of Medicine, Uşak University, Uşak, Turkey.
Deparment of General Surgery, Koru Ankara Hospital, Ankara, Turkey.
Turk J Med Sci. 2021 Oct 21;51(5):2485-2493. doi: 10.3906/sag-2009-158.
BACKGROUND/AIM: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. In addition, the relationship between omentin-1 and laboratory and clinical parameters commonly used in intensive care units (ICUs) was evaluated.
One hundred and fifty-four patients hospitalized in the surgical ICU were included in the study. Blood samples for omentin-1 were collected from the patients displaying clinical condition changes. Changes in omentin-1 levels were observed during the hospital stay of the patients. A total of 423 blood samples were evaluated. Omentin-1 levels were compared to the laboratory parameters routinely monitored in the ICU and the prognostic significance of omentin-1 for surgical intensive care patients was investigated.
The median APACHE II score of all patients was (median-IQR, 8.0–6.0 ng/mL). Omentin-1 levels of the alive patients in the ICU (median-IQR, 339.04–407.68 ng/mL) were significantly higher compared to dead patients (median-IQR, 166.40–363.60 ng/mL). Omentin-1 levels were higher in nonsepsis patients compared to the levels of the patients in sepsis and septic shock (p < 0.001). Omentin-1 values were negatively correlated with the C-reactive protein and procalcitonin levels, body temperature, and the SOFA (sequential organ failure assessment score) scores and they were positively correlated with albumin, prealbumin, and glucose levels.
Omentin-1 may play a role in the complex constructs of inflammation and metabolic events in intensive care patients. Reduced omentin-1 levels in surgical intensive care patients were associated with poor prognosis and increased mortality.
背景/目的：网膜素-1 是脂肪因子家族的一员，选择性地从内脏脂肪组织和大网膜中分泌。已经表明，网膜素-1 参与某些疾病的发病机制，并可用作预后标志物。本研究首次调查了网膜素-1 在外科重症监护患者中的预后意义。此外，还评估了网膜素-1 与重症监护病房（ICU）中常用的实验室和临床参数之间的关系。
本研究纳入了 154 名住院于外科 ICU 的患者。从显示临床病情变化的患者中采集了用于网膜素-1 的血液样本。观察了患者住院期间网膜素-1 水平的变化。共评估了 423 份血样。将网膜素-1 水平与 ICU 中常规监测的实验室参数进行了比较，并研究了网膜素-1 对外科重症监护患者的预后意义。
所有患者的中位急性生理学和慢性健康评估 II 评分（APACHE II）均为（中位数-IQR，8.0-6.0ng/mL）。存活于 ICU 的患者（中位数-IQR，339.04-407.68ng/mL）的网膜素-1 水平明显高于死亡患者（中位数-IQR，166.40-363.60ng/mL）。非脓毒症患者的网膜素-1 水平高于脓毒症和感染性休克患者（p<0.001）。网膜素-1 值与 C 反应蛋白和降钙素原水平、体温以及序贯器官衰竭评估（SOFA）评分呈负相关，与白蛋白、前白蛋白和葡萄糖水平呈正相关。
网膜素-1 可能在重症监护患者的炎症和代谢事件的复杂结构中发挥作用。外科重症监护患者中网膜素-1 水平降低与预后不良和死亡率增加相关。
