De Mey A, Govaerts M J, Widera I
Acta Anaesthesiol Belg. 1985 Sep;36(3):189-93.
In the paediatric burn unit of Brugmann University Hospital, children are treated conservatively for three weeks before excision and grafting. In order to avoid excessive bleeding during tangential excision of the granulating tissue, sub-eschar infiltration with Para-Ornithin-8-Vasopressin (POR 8), a synthetic neurohypophyseal-like hormone, has been performed since 1979 on 145 children. Bleeding is reduced dramatically by this technique. Therefore, since 1984, infiltration of the donor site with POR 8 was also performed in 25 children. Excision and grafting of areas up to 20% of total body surface are possible in one operation with a graft take rate of 95 to 100%. We didn't record any variation in heart rate. A 5 to 10% increase of arterial blood pressure occurred in all children. No general or local complications have been observed. We believe this technique to be of great help in the operative treatment of burns in children.
在布鲁格曼大学医院的儿科烧伤病房，儿童在进行切除和植皮手术前会接受三周的保守治疗。为了避免在肉芽组织的削痂术中出现过多出血，自1979年以来，已对145名儿童进行了皮下注射合成的类似神经垂体激素的对羟基鸟氨酸 - 8 - 加压素（POR 8）。通过这种技术，出血显著减少。因此，自1984年以来，也对25名儿童的供皮区进行了POR 8浸润。一次手术可以切除和移植高达全身表面积20%的区域，植皮成活率为95%至100%。我们没有记录到心率有任何变化。所有儿童的动脉血压均升高了5%至10%。未观察到全身或局部并发症。我们认为这项技术对儿童烧伤的手术治疗有很大帮助。
