Syrjänen S, Markkanen H, Syrjänen K
Acta Odontol Scand. 1985 Jul;43(3):133-8. doi: 10.3109/00016358509064143.
The beta 2-microglobulin (beta 2-m) pattern in gingival biopsy specimen from 24 patients with chronic severe periodontitis (P), from 11 patients with juvenile periodontitis (JP), and from 24 periodontally healthy subjects (CO) was studied with an indirect immunoperoxidase method. No reactivity for beta 2-m was found in 71% of specimens in the P and CO groups, whereas 82% of the JP specimens showed positive beta 2-m staining in the epithelium. The reactivity was detected mostly in the upper layers of the epithelium. In all the three groups the beta 2-m reactivity was less frequent in the subepithelial connective tissue than in the epithelium proper, and it seemed to be confined to the inflammatory cells. In the JP group, prominent reactivity for beta 2-m was also located in intercellular bridges of the squamous cells. The significance of the results is discussed in terms of the cell differentiation in these diseases, including the function of beta 2-m related to the function of the classical HLA antigens (HLA-A, HLA-B, HLA-C).
采用间接免疫过氧化物酶法，对24例慢性重度牙周炎患者（P组）、11例青少年牙周炎患者（JP组）以及24例牙周健康受试者（CO组）牙龈活检标本中的β2-微球蛋白（β2-m）模式进行了研究。P组和CO组71%的标本未发现β2-m反应性，而82%的JP组标本上皮中β2-m染色呈阳性。反应性主要在上皮上层检测到。在所有三组中，β2-m反应性在下上皮结缔组织中比在固有上皮中出现得少，且似乎局限于炎症细胞。在JP组中，β2-m的显著反应性也位于鳞状细胞的细胞间桥中。根据这些疾病中的细胞分化情况，包括β2-m与经典HLA抗原（HLA-A、HLA-B、HLA-C）功能相关的功能，对结果的意义进行了讨论。
