Abou-Azma N E, Ghoneium S, Abdel-Razzak M Y
Department of Oral Pathology, Faculty of Dentistry, Tanta University.
Egypt Dent J. 1994 Jan;40(1):611-6.
Inflammation of human gingival tissues including the periodontal structures occurs in response to infection in crevicular sulcus caused by microorganisms which first attach to the surface of oral squamous epithelium, penetrate into inner gingival epithelium and finally through the basement membrane of the underlying connective tissue (Murase et al., 1985). Other authors have long held the view that periodontitis is not a homogeneous disease entity but rather a group of family related diseases manifesting similar features and different etiologic factors. Immunological mechanism have long been implicated in pathogenesis of chronic periodontitis. Defect of host mechanism may have a relationship in development of rapidly progressive periodontitis (RPP) (Page et al., 1983).
人类牙龈组织（包括牙周结构）的炎症是对龈沟感染的反应，这种感染由微生物引起，微生物首先附着于口腔鳞状上皮表面，穿透至牙龈上皮内层，最终穿过下方结缔组织的基底膜（村濑等人，1985年）。其他作者长期以来一直认为，牙周炎不是一种单一的疾病实体，而是一组具有相似特征和不同病因的家族性相关疾病。免疫机制长期以来一直被认为与慢性牙周炎的发病机制有关。宿主机制缺陷可能与快速进展性牙周炎（RPP）的发展有关（佩奇等人，1983年）。
