地尔硫䓬及其他钙通道阻滞剂的一些心脏外效应。

Some extracardiac effects of diltiazem and other calcium entry blockers.

作者信息

Andersson K E

出版信息

Acta Pharmacol Toxicol (Copenh). 1985;57 Suppl 2:31-43. doi: 10.1111/j.1600-0773.1985.tb03572.x.

DOI:10.1111/j.1600-0773.1985.tb03572.x

Abstract

Calcium entry blockers have a well documented relaxing effect of smooth muscle, vascular as well as non-vascular. Mainly as a consequence of this action, the drugs have been used for treatment of several non-cardiac disorders where hyperactivity of smooth muscle is considered to have an important role in the pathogenesis. In this short review some of these extracardiac effects of calcium entry blockers are discussed and also their clinical application.

摘要

钙通道阻滞剂对平滑肌（包括血管平滑肌和非血管平滑肌）具有明确的舒张作用。主要由于这一作用，这类药物已被用于治疗多种非心脏疾病，在这些疾病中，平滑肌功能亢进被认为在发病机制中起重要作用。在这篇简短的综述中，将讨论钙通道阻滞剂的一些心脏外效应及其临床应用。