平滑肌疾病中的钙通道阻滞剂。现状。

Calcium blockers in smooth-muscle disorders. Current status.

作者信息

Schwartz M L, Rotmensch H H, Vlasses P H, Ferguson R K

出版信息

Arch Intern Med. 1984 Jul;144(7):1425-9.

Abstract

Calcium-entry blockers have proven efficacy in a variety of cardiovascular disorders. The effects of these agents on ionic calcium fluxes and, thus, on smooth-muscle contraction suggest that several noncardiac conditions involving smooth-muscle dysfunction may be managed with calcium antagonists. Beneficial therapeutic results have been reported in various forms of hypertension and Raynaud's phenomenon. The results of preliminary studies in treating pulmonary hypertension, cerebral arterial spasm, migraine headache, esophageal motility disorders, and myometrial hypercontractile states are encouraging. Carefully designed, large-scale and long-term clinical trials are needed to establish the therapeutic value of calcium-entry blockers in these disorders.

摘要

钙通道阻滞剂已被证明在多种心血管疾病中具有疗效。这些药物对离子钙通量的影响，进而对平滑肌收缩的影响表明，一些涉及平滑肌功能障碍的非心脏疾病可能可用钙拮抗剂治疗。在各种形式的高血压和雷诺现象中已报道了有益的治疗效果。治疗肺动脉高压、脑动脉痉挛、偏头痛、食管动力障碍和子宫肌层过度收缩状态的初步研究结果令人鼓舞。需要精心设计的大规模长期临床试验来确定钙通道阻滞剂在这些疾病中的治疗价值。