School of Food and Biological Engineering, Yantai Institute of Technology, Yantai 264003, China; Department of College of Biological Science and Technology, Yangzhou University, Yangzhou 225009, China.
Department of College of Biological Science and Technology, Yangzhou University, Yangzhou 225009, China.
Gen Comp Endocrinol. 2024 Oct 1;357:114592. doi: 10.1016/j.ygcen.2024.114592. Epub 2024 Jul 21.
Adiponectin regulates steroid production and influences gonadal development. This study examined the effects of tannic acid (TA) on the adiponectin levels and gonads of male Brandt's voles. Male Brandt's voles aged 90 d were randomly separated into three groups: a control group (provided distilled water), a group given 600 mg∙kg-1 TA, and a group that received 1200 mg∙kg-1 TA (continuous gavage for 18 d). In this study, we examined the effects of TA on the adiponectin, antioxidant, and inflammatory levels in the testes. Furthermore, we examined the expression of important regulatory elements that influence adiponectin expression and glucose utilisation. In addition, the body weight, reproductive organ weight, and testicular shape were assessed. Our study observed that TA treatment increased serum adiponectin levels, DsbA-L and Ero1-Lα transcription levels, and AdipoR1, AMPK, GLUT1, and MCT4 expression levels in testicular tissue. TA enhanced pyruvate and lactic acid levels in the testicular tissue, boosted catalase activity, and reduced MDA concentrations. TA reduced the release of inflammatory factors in the testicular tissues of male Brandt's voles. TA increased the inner diameter of the seminiferous tubules. In conclusion, TA appears to stimulate adiponectin secretion and gonadal growth in male Brandt's voles while acting as an antioxidant and anti-inflammatory agent.
脂联素调节类固醇的产生并影响性腺发育。本研究探讨了单宁酸（TA）对雄性布氏田鼠脂联素水平和性腺的影响。90 日龄雄性布氏田鼠随机分为三组：对照组（给予蒸馏水）、600mg·kg-1 TA 组和 1200mg·kg-1 TA 组（连续灌胃 18 天）。本研究探讨了 TA 对睾丸中脂联素、抗氧化和炎症水平的影响。此外，还研究了影响脂联素表达和葡萄糖利用的重要调节因子的表达。此外，还评估了体重、生殖器官重量和睾丸形状。我们的研究观察到，TA 处理增加了血清脂联素水平、DsbA-L 和 Ero1-Lα 转录水平以及睾丸组织中 AdipoR1、AMPK、GLUT1 和 MCT4 的表达水平。TA 增加了睾丸组织中的丙酮酸和乳酸水平，提高了过氧化氢酶活性，降低了 MDA 浓度。TA 减少了睾丸组织中炎症因子的释放。TA 增加了曲细精管的内径。总之，TA 似乎刺激雄性布氏田鼠脂联素的分泌和性腺的生长，同时具有抗氧化和抗炎作用。
