Emerg Infect Dis. 2024 Aug;30(8):1589-1598. doi: 10.3201/eid3008.240031.
To determine the characteristics of pediatric patients 0-19 years of age who died after onset of SARS-CoV-2 infection in Japan during January 1-September 30, 2022, we reviewed multiple sources. We identified 62 cases, collected detailed information from medical records and death certificates, and conducted interviews, resulting in 53 patients with detailed information for our study. Among 46 patients with internal causes of death (i.e., not external causes such as trauma), 15% were <1 year of age, 59% had no underlying disease, and 88% eligible for vaccination were unvaccinated. Nonrespiratory symptoms were more common than respiratory symptoms. Out-of-hospital cardiac arrest affected 46% of patients, and time from symptom onset to death was <7 days for 77%. Main suspected causes of death were central nervous system abnormalities (35%) and cardiac abnormalities (20%). We recommend careful follow-up of pediatric patients after SARS-CoV-2 infection during the first week after symptom onset, regardless of underlying diseases.
为了确定 2022 年 1 月 1 日至 9 月 30 日期间在日本发病后因 SARS-CoV-2 感染而死亡的 0-19 岁儿科患者的特征，我们查阅了多种资料来源。我们共发现了 62 例病例，从病历和死亡证明中收集了详细信息，并进行了访谈，最终对 53 例有详细信息的患者进行了研究。在 46 例死因属于内部原因（即非创伤等外部原因）的患者中，15%的患者年龄<1 岁，59%的患者没有基础疾病，且 88%符合接种条件的患者未接种疫苗。非呼吸系统症状比呼吸系统症状更为常见。46%的患者发生院外心脏骤停，77%的患者从症状出现到死亡的时间<7 天。主要的疑似死因是中枢神经系统异常（35%）和心脏异常（20%）。我们建议在症状出现后的第一周内对 SARS-CoV-2 感染的儿科患者进行密切随访，无论其是否存在基础疾病。
