评价药用植物 Baccaurea ramiflora 和 Microcos paniculata 的乙醇提取物的抗氧化和抗菌活性。
Evaluation of Antioxidant and Antimicrobial Activity of Ethanolic Extract of Medicinal Plants Baccaurea Ramiflora and Microcos Paniculata.
机构信息
Associate Professor, Department of Pharmacology, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad-500043, Telangana, India.
Department of Pharmacology, NET Pharmacy College, Raichur, India.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jul 24;40:e20240014. doi: 10.62958/j.cjap.2024.014.
OBJECTIVE
The present study was undertaken to investigate the antioxidant and antimicrobial effect of ethanolic leaf extract of Baccaurea ramiflora and Microcos paniculata.
METHODS
DPPH radical scavenging activity, Nitric oxide scavenging activity, Super oxide anion radical scavenging activity, Reducing power assay were used to assess antioxidant efficacy. Zone of Inhibition determination by Agar well diffusion assay was used to assess antimicrobial activity.
RESULTS
The Baccaurea ramiflora and Microcos paniculata leaves extracted with different solvents such as petroleum ether, chloroform, ethanol and water among that in leaves ethanolic extract produce 10.78, 10.38 percentage yield respectively. Both the extracts subjected for phytochemical investigation revealed the presence of alkaloids, glycosides, tannins, saponins, proteins and flavonoids. Ethanolic extract of Baccaurea ramiflora showed maximum inhibition zone diameter was obtained in Salmonella typhi (Gram-negative bacteria) with diameter 29 mm and 25 mm respectively at 200mg/ml and 100mg/ml. Similarly, Ethanolic extract of Microcos paniculata showed minimum inhibition zone diameter compare to Baccaurea ramiflora was obtained in Salmonella typhi (Gram-negative bacteria) with diameter 23 mm and 19 mm respectively at 200mg/ml and 100mg/ml. Ethanolic extract of Baccaurea ramiflora showed maximum inhibition zone diameter was obtained in Aspergillus fumigates with diameter 25 mm and 22 mm respectively at 200mg/ml and 100mg/ml. Similarly, Ethanolic extract of Microcos paniculata showed minimum inhibition zone diameter compare to Baccaurea ramiflora was obtained in Aspergillus fumigates with diameter 21 mm and 19 mm respectively at 200mg/ml and 100mg/ml.
CONCLUSION
The current findings point to Baccaurea ramiflora and Microcos paniculata antioxidant and antimicrobial properties. However future studies should be designed to isolate the active constituents responsible for the specified effect.
目的
本研究旨在探讨 Baccaurea ramiflora 和 Microcos paniculata 叶乙醇提取物的抗氧化和抗菌作用。
方法
采用 DPPH 自由基清除活性、一氧化氮清除活性、超氧阴离子自由基清除活性、还原力测定法评估抗氧化功效。采用琼脂孔扩散法测定抑菌圈直径来评估抗菌活性。
结果
从 Baccaurea ramiflora 和 Microcos paniculata 的不同溶剂（如石油醚、氯仿、乙醇和水）中提取的叶子，其中叶子的乙醇提取物分别产生 10.78%和 10.38%的产率。两种提取物进行植物化学研究均显示存在生物碱、糖苷、单宁、皂苷、蛋白质和类黄酮。 Baccaurea ramiflora 的乙醇提取物在 200mg/ml 和 100mg/ml 时对伤寒沙门氏菌（革兰氏阴性菌）的最大抑菌圈直径分别为 29mm 和 25mm。同样， Baccaurea ramiflora 的乙醇提取物在 200mg/ml 和 100mg/ml 时对伤寒沙门氏菌（革兰氏阴性菌）的最小抑菌圈直径分别为 23mm 和 19mm。 Baccaurea ramiflora 的乙醇提取物在 200mg/ml 和 100mg/ml 时对烟曲霉的最大抑菌圈直径分别为 25mm 和 22mm。同样， Baccaurea ramiflora 的乙醇提取物在 200mg/ml 和 100mg/ml 时对烟曲霉的最小抑菌圈直径分别为 21mm 和 19mm。
结论
目前的研究结果表明 Baccaurea ramiflora 和 Microcos paniculata 具有抗氧化和抗菌特性。然而，未来的研究应设计用于分离负责特定作用的活性成分。
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