Assistant Professor, Department of Pharmacology, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad-500043, India.
Associate Professor, Department of Pharmacology, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad-500043, India.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jul 24;40:e20240015. doi: 10.62958/j.cjap.2024.015.
To evaluate synergistic antiulcer activity of ethanolic extracts of Tephrosia purpurea and Bacopa monnieri in ulcer induced rats.
Ethanolic leaf extracts of both the plants were administered individually and in combination at a dose of 200mg/kg to ulcer induced male albino rats. Omeprazole 10mg/kg was used as standard. Pylorus ligation method, ethanol and indomethacin induced gastric ulcer models were the different gastric ulcer models selected for the induction of ulcer in rats. Ulcer index, ulcer score, total acidity, pH, percentage protection, volume of gastric juice were the parameters evaluated and compared in different groups in all the models.
Decrease in the ulcer score, ulcer index, total acidity was observed and percentage protection was significant(*p<0.05 and p<0.01) with the combination extract compared to group received individual plant extracts.
Our results suggested that combination of two medicinal plants showed synergistic anti ulcer activity and decreased the formation of ulcer lesions in rats.
评价白花蝴蝶草和墨旱莲乙醇提取物在溃疡诱导大鼠中的协同抗溃疡活性。
分别给予两种植物的乙醇叶提取物，并以 200mg/kg 的剂量联合给予溃疡诱导的雄性白化大鼠。奥美拉唑 10mg/kg 为标准。幽门结扎法、乙醇和吲哚美辛诱导的胃溃疡模型是为在大鼠中诱导溃疡而选择的不同胃溃疡模型。在所有模型中，评估和比较了不同组的溃疡指数、溃疡评分、总酸度、pH 值、保护率百分比和胃液量等参数。
与单独接受植物提取物的组相比，组合提取物可观察到溃疡评分、溃疡指数和总酸度降低，保护率显著（*p<0.05 和 p<0.01）。
我们的结果表明，两种药用植物的组合表现出协同抗溃疡活性，并减少了大鼠溃疡病变的形成。
